环泊酚在(支)气管镜诊疗镇痛/麻醉中的应用

Application of ciprofol in analgesia/anesthesia with bronchoscopy diagnosis and treatment

目的探索环泊酚在(支)气管镜诊疗镇痛/麻醉中应用的安全性,是否能成为代替丙泊酚的更优选择。方法选择2023年11月至2024年1月潍坊市第二人民医院内窥镜室择期行无插管麻醉下(支)气管镜诊疗的患者63例,将患者根据随机数表法分为环泊酚组(n=32)和丙泊酚组(n=31)。记录患者一般资料及入室后血压(BP)、心率(HR)、呼吸频率(RR)变化趋势,是否出现严重的循环抑制,追加药物情况。结果两组患者在麻醉中BP、HR的比较,差异无统计学意义(P>0.05),但环泊酚组在T1、T4时刻RR高于丙泊酚组,差异有统计学意义(P<0.05)。两组的追加药物情况比较,差异无统计学意义(P>0.05)。环泊酚组低血压、心动过缓发生率低于丙泊酚组,但只有心动过缓发生率差异有统计学意义(P<0.05)。结论环泊酚在(支)气管镜诊疗镇痛/麻醉中可明显减少呼吸抑制,低血压、心动过缓发生率低,但0.3 mg/kg的剂量可能需要酌情增加。

Objective To explore the safety of ciprofol in the application of analgesia/anesthesia with bronchoscopy diagnosis and treatment,and whether it can be a better choice to replace propofol.Methods A total of 63 patients who underwent elective bronchoscopy without intubation anesthesia in the endoscopy room of Weifang No.2 People’s Hospital from November 2023 to January 2024 were selected.The patients were randomly divided into two groups using a digital randomization method:ciprofol group(n=32)and propofol group(n=31).The general information of the patient and the trend of changes in blood pressure(BP),heart rate(HR),and respiratory rate(RR)after entering the room,whether there was severe circulatory suppression,and whether additional medication was needed were recorded.Results There was no statistically significant difference in BP and HR between the two groups of patients during anesthesia(P>0.05),but the RR of ciprofol group was higher than that of propofol group at T1 and T4,and the difference was statistically significant(P<0.05).The comparison of additional medication between the two groups showed no statistically significant difference(P>0.05).The incidence of hypotension and bradycardia in ciprofol group was lower than that in propofol group,but only the difference in the incidence of bradycardia was statistically significant(P<0.05).Conclusion Ciprofol can significantly reduce respiratory depression and lower the incidence of hypotension and bradycardia in the analgesia/anesthesia with bronchoscopy diagnosis and treatment,but the dose of 0.3 mg/kg may need to be increased as appropriate.