倪青教授诊治糖尿病的临证经验及用药规律研究

Clinical Experience and Medication Regularity of Professor NI Qing against Diabetes

目的通过数据挖掘研究倪青教授治疗糖尿病(Diabetes mellitus,DM)的用药规律及核心处方,探讨倪青教授诊治DM早期的临证经验及学术思想。方法通过临床医案采集,结合软件的分析系统,采用频次统计法,统计得出治法出现频次及中药性味归经频次;采用关联规则分析法,统计得出处方中药物组合使用频次及药物之间的关联规则,采用Cytoscape 3.7.1进行可视化展示。结果通过对99例DM早期患者进行分析,高频药物有茯苓,泽泻,甘草,猪苓,佩兰,藿香等;药物组合有“猪苓,茯苓”“猪苓,泽泻”“藿香,佩兰”“厚朴,半夏”“炒白术,茯苓”“车前子,川牛膝”“太子参,茯苓”“冬瓜仁,冬瓜皮”“泽兰,泽泻”“生黄芪,太子参”“檀香,丹参,砂仁”等。结论倪青教授辨证治疗DM早期重视病证结合,从湿、虚、瘀、浊着手,治以健脾祛湿,疏瘀化浊。

Objective To investigate the medication regularity and core prescription of professor NI Qing against diabetes by data mining in order to provide references for the clinical treatment of diabetes mellitus(DM).Methods By collecting clinical medical records and combining them with the analysis system of the software,the frequency statistics method was used to calculate the occurrence frequency of treatment methods and the frequency of properties and flavors of traditional Chinese medicine(TCM)acting on different channels.Association rule analysis was used to statistically determine the frequency of TCM drug combinations used in the prescriptions and the association rules between drugs.Cytoscape 3.7.1 was adopted for visual display.Results A total of 99 cases of patients with early DM were analyzed.Drugs with high frequency include Poria,Rhizoma Alismatis,Radix et Rhizoma Glycyrrhizae,Polyporus Umbellatus,Eupatorii Herba,and Herba Pogostemonis.The drug combinations include“Polyporus Umbellatus+Poria”,“Polyporus Umbellatus+Rhizoma Alismatis”,“Herba Pogostemonis+Eupatorii Herba”,“Cortex Magnoliae Officinalis+Rhizoma Pinelliae”,“fried Rhizoma Atractylodis Macrocephalae+Poria”,“Semen Plantaginis+Cyathulae Radix”,“Radix Pseudostellariae+Poria”,“Semen Benincasae+Exocarpium Benincasae”,“Eupatorium japonicum+Rhizoma Alismatis”,“raw Radix Astragali+Radix Pseudostellariae”,and“Lignum Santalialbi+Radix et Rhizoma Salviae Miltiorrhizae+Fructus Amomi”.Conclusion Professor NI Qing attaches great importance to the symptoms in the diagnosis and treatment of early DM,starting with dampness,deficiency,blood stasis,and turbidity to treat the disease by strengthening the spleen,removing dampness,and removing blood stasis and turbidity.