中药灌肠联合美沙拉嗪肠溶片治疗溃疡性结肠炎患者疗效及对血小板和凝血功能及炎性因子的影响

Effect of enema combined with mesalazine enteric-coated tablets on patients with ulcerative colitis and its effect on platelets and coagulation function and inflammatory factors

目的探讨中药灌肠联合美沙拉嗪肠溶片治疗溃疡性结肠炎患者疗效及对血小板、凝血功能及炎性因子的影响。方法选取南阳市中心医院肛肠科收治的溃疡性结肠炎患者118例作为此次研究对象,纳入时间2021年8月13日—2022年8月13日,根据治疗方法将患者分成两组,每组各59例,分别为普通组和混合组,其中普通组患者口服美沙拉嗪肠溶片实施常规治疗,混合组患者采取中药灌肠联合美沙拉嗪肠溶片治疗,最后分别对比两组患者的疗效、凝血功能和血小板指标、炎性因子水平、生活质量、肠镜评分及肠道黏膜屏障功能指标。结果普通组患者的治疗有效率为83.05%,低于混合组患者的有效率(98.31%);混合组患者的血浆纤维蛋白原(Fib)和血小板计数(PLT)指标明显优于普通组;混合组患者肿瘤坏死因子-α(TNF-α)、白细胞介素-8(IL-8)及白细胞介素-6(IL-6)指标均优于普通组;混合组患者的肠镜评分及肠道黏膜屏障功能指标均优于普通组(P<0.05)。结论中西医结合治疗溃疡性结肠炎患者,能够显著提升疗效,提高患者血小板和凝血功能及肠道黏膜屏障功能,降低炎性因子水平。

Objective To discuss the therapeutic effect of enema combined with mesalazine enteric-coated tablets in the treatment of ulcerative colitis and the effects on platelets,coagulation function and inflammatory factors.Methods A total of 118 patients with ulcerative colitis admitted to the Department of Anorectal of Nanyang Central Hospital were selected as subjects of this study.The patients were included from August 13,2021 to August 13,2022.According to the treatment methods,the patients were divided into two groups with 59 patients in each group,and the groups were named ordinary group and mixed group respectively.Patients in the normal group were treated with mesalazine enteric-coated tablets orally.Patients in the mixed group were treated with traditional Chinese medicine enema combined with mesalazine enteric-coated tablets.Finally,the efficacy,coagulation function and platelet indexes,inflammatory factor levels,quality of life,colonoscopy score and intestinal mucosal barrier function indexes of the two groups were compared respectively.Results The effective rate of the common group was 83.05%,lower than that of the mixed group(98.31%).The plasma fibrinogen(Fib)and platelet count(PLT)indexes of mixed group were significantly better than those of normal group;tumor necrosis factorα(TNF-α),interleukin8(IL-8)and 6(IL-6)indexes in mixed group were better than those in normal group.The colonoscopy scores and intestinal mucosal barrier function indexes of mixed group were better than those of common group(P<0.05).Conclusion The combination of traditional Chinese and western medicine in the treatment of patients with ulcerative colitis can significantly improve the efficacy,improve the platelet and coagulation function,reduce the level of inflammatory factors,and improve the intestinal mucosal barrier function.The effect is significant,which is worthy of long-term clinical promotion and use.