细胞间相互作用及代谢微环境在动脉钙化中的作用机制研究进展

Research progress on the mechanism of intercellular communication and metabolic microenvironment in arterial calcification

动脉钙化是一种主要表现为钙磷等矿物质易位沉积于动脉管壁的病理过程,常继发于多种疾病,细胞间通信及相互作用在动脉钙化的发展过程中发挥着重要作用。血管平滑肌细胞表型转换尽管被认为是动脉钙化的主要特征,但导致其收缩表型丧失和驱使钙化表型转化的机制目前还不完全清楚。本综述旨在总结近年来血管平滑肌细胞表型转换及与不同细胞之间相互作用和体内代谢微环境在动脉钙化发展研究中的最新进展,以进一步了解动脉钙化的相关机制。

Arterial calcification is a pathological process characterized by the translocation of minerals such as calcium and phosphorus onto the arterial wall,which is often secondary to a variety of diseases.Intercellular communication and interaction play an important role in the development of arterial calcification.Although the phenotypic transition of vassular smooth muscle cells is considered to be a main feature of arterial calcification,the mechanism leading to the loss of contractile phenotype and driving the phenotypic transformation of calcification is not fully understood.The purpose of this review is to summarize the latest progress in the study of phenotypic transformation of vascular smooth muscle cells,their communication with different cells,and the metabolic microenvironment in vivo in the development of arterial calcification,so as to further understand the mechanism of arterial calcification.