子宫内膜癌MKI67表达与预后的相关性

Correlation between MKI67 expression and prognosis in endometrial cancer

目的分析MKI67表达与子宫内膜癌患者临床病理特征及预后的相关性。方法选择2009年1月至2021年12月于广西梧州市红十字会医院接受手术治疗的322例患者。使用logistic回归分析MKI67表达与临床病理特征的相关性,使用Kaplan-Meier曲线、Log-rank检验和Cox回归分析MKI67表达与预后之间的关系。结果子宫内膜癌MKI67表达水平与临床病理特征之间存在相关性。MKI67表达和p53水平呈正相关,与雌激素受体(estrogen receptor,ER)和孕激素受体(progesterone receptor,PR)表达水平呈负相关。Cox回归表明MKI67是子宫内膜癌患者术后死亡的危险因素(HR=4.27,95%CI:1.17~15.59);Kaplan-Meier生存曲线显示,相较于MKI67高表达患者,MKI67低表达患者的总生存时间更长,差异有统计学意义(P=0.016)。结论MKI67表达与p53、ER、PR等临床病理特征密切相关。MKI67的表达水平和子宫内膜癌患者的预后相关,MKI67高表达的子宫内膜癌患者的生存率较低。

Objective To analyze the correlation between MKI67 expression and clinicopathological features and prognosis of endometrial cancer patients.Methods Totally 322 patients who underwent surgical treatment from January 2009 to December 2021 in the Red Cross Hospital of Wuzhou City,Guangxi Province,were selected.The correlation between MKI67 expression and clinicopathological characteristics was analyzed using logistic regression,and the association between MKI67 expression and prognosis was analyzed using Kaplan-Meier curves,Log-rank test and Cox regression.Results There was a correlation between MKI67 expression levels and clinicopathological features in endometrial cancer.MKI67 expression was positively correlated with p53 expression levels and negatively correlated with ER and PR expression levels.Cox regression demonstrated that MKI67 was a risk factor for postoperative death in patients with endometrial cancer(HR=4.27,95%CI:1.17-15.59);Kaplan-Meier survival curves showed that patients with low MKI67 expression had longer overall survival time compared to patients with high MKI67 expression,and the difference was statistically significant(P=0.016).Conclusion MKI67 expression is closely associated with clinicopathologic features such as p53,ER,and PR.The expression level of MKI67 is correlated with the prognosis of endometrial cancer patients,and patients with endometrial cancer with high MKI67 expression have a lower survival rate.