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不同组织的运动因子及其功能研究进展

Research Progress on Exerkines and Their Functions in Different Tissues
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摘要 运动是预防和治疗肥胖、胰岛素抵抗等代谢相关疾病的有效策略。运动因子是由运动诱导的可溶性信号因子,主要包括肝脏因子、肌肉因子和脂肪因子,在运动对机体代谢的调节中起重要作用。运动因子可以加速体内脂肪氧化分解,诱导白色脂肪组织褐变,优化机体能量分配,控制食欲和能量消耗,并减少全身炎症和胰岛素抵抗。目前已知的肝脏因子主要有成纤维细胞生长因子21、血管生成素样蛋白4和卵泡抑素;肌肉因子主要有白细胞介素6、鸢尾素、肌肉生长抑制素和β-氨基异丁酸;脂肪因子主要有瘦素和脂联素。本文主要总结了这些运动因子的功能以及运动期间涉及的代谢途径与对各器官串联调控的机制。 Exercise is an effective strategy for the prevention and treatment of metabolism-related diseases such as obesity and insulin resistance.Exerkines factors are soluble signaling factors induced by exercise,mainly including hepatokines,myokines and adipokines,which play an important role in the regulation of body metabolism by exercise.Exerkines can increase the oxidative decomposition of fat in the body,induce browning of white adipose tissue,optimize the body' s energy redistribution,control appetite and energy expenditure,and reduce systemic inflammation and insulin resistance.At present,the main known hepatokines are fibroblast growth factor 21,angiopoietin-like protein 4and follistatin,myokines mainly include interleukin 6,irisin,myostatin and β-aminoisobutyric acid,and adipokines are mainly leptin and adiponectin.This article mainly summarizes the functions of these exerkines,the metabolic pathways involved during exercise,and the mechanism of tandem regulation of various organs.
作者 韩冰倩 HAN Bingqian(College of Life Sciences,Wuhan University,Wuhan 430072,China)
出处 《生物化工》 CAS 2024年第4期207-211,共5页 Biological Chemical Engineering
关键词 运动 运动因子 肝脏因子 肌肉因子 脂肪因子 exercise exerkines hepatokines myokines adipokines
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