血清lncRNA MALAT1水平与糖尿病性黄斑水肿发生及严重程度的关系

Correlation of serum lncRNA MALAT1 level with development and severity of diabetic macular edema

目的探讨血清长链非编码RNA(lncRNA)中转移相关肺腺癌转录本1(MALAT1)水平与糖尿病性黄斑水肿(DME)发生及严重程度的关系。方法队列研究。抽取2019年10月至2023年10月西安医学院第二附属医院收治的110例DME患者作为研究组,同时抽取80例健康者作为对照组,比较两组lncRNA MALAT1、糖化血红蛋白及空腹血糖水平。结果研究组lncRNA MALAT1、糖化血红蛋白、空腹血糖水平高于对照组(P<0.05);研究组轻、中、重度水肿患者lncRNA MALAT1、糖化血红蛋白、空腹血糖水平均高于对照组,且三组患者lncRNA MALAT1、糖化血红蛋白、空腹血糖水平比较差异有统计学意义(P<0.05)。研究组患者lncRNA MALAT1与黄斑中心凹视网膜厚度呈正相关(r=0.49,P=0.026)。多因素分析发现糖尿病病程及lncRNA MALAT1均是2型糖尿病患者出现DME的危险因素(P<0.05)。结论lncRNA MALAT1在DME患者血清中高表达,且与DME患者严重程度呈正相关,其对评估DME患者病情严重程度可能具有一定价值。

Objective To investigate the correlation of level of serum long noncoding RNA(lncRNA)metastasis-associated lung adenocarcinoma transcript 1(MALAT1)with the development and severity of diabetic macular edema(DME).Methods This study was a cohort study.A total of 110 patients with DME admitted to the Second Affiliated Hospital of Xi’an Medical University from October 2019 to October 2023 were selected as the study group,at the same time,80 healthy individuals were selected as the control group.The levels of lncRNA MALAT1,glycated haemoglobin and fasting blood glucose were compared between the two groups.Results The levels of lncRNA MALAT1,glycated hemoglobin,and fasting blood glucose in the study group were higher than those in the control group(P<0.05).The average levels of lncRNA MALAT1,glycated hemoglobin,and fasting blood glucose in patients with mild,moderate,and severe edema in the study group were all higher than those in the control group,and there were statistically significant differences in levels of lncRNA MALAT1,glycated hemoglobin,and fasting blood glucose among patients with mild,moderate,and severe edema(P<0.05).There was a positive correlation between lncRNA MALAT1 and central macular thickness in the study group(r=0.49,P=0.026);multivariate logistic regression analysis revealed that both the duration of diabetes and lncRNA MALAT1 were risk factors for the development of DME in patients with type 2 diabetes mellitus(P<0.05).Conclusions lncRNA MALAT1 is highly expressed in the serum of DME patients,and is positively correlated with the severity of DME.It may have some value in evaluating the severity of DME patients.