Adhesion G protein-coupled receptor latrophilin 1(ADGRL1):a novel regulator of glucose and energy homeostasis

Recently,I read with interest the research article entitled'Dysfunction of the adhesion G protein-coupled receptor latrophilin 1(ADGRL1/LPHN1)increases the risk of obesity published in Signal Transduction and Targeted Therapy.This report confirms and extends our findings that ADGRL1(aka latrophilin 1)regulates energy balance and glucose homeostasis.?Using affinity chromatography coupled with proteomics and electrophysiology,we showed that ADGRL1 is likely a glucose receptor in the hypothalamus.Our findings demonstrated that lack of ADGRL1 in the hypothalamus or whole-body causes obesity and features of type 2 diabetes in mice.It is refreshing to see Dietzsch et al.i reached the same conclusion.