期刊文献+

Prosaposin hyperglycosylation: a novel tumor immune escape mechanism and implications for cancer immunotherapy

原文传递
导出
摘要 In a recent article published in Science,Sharma et al.describes the essential role of saposins in cross-presentation of tumor membraneassociated antigens by dendritic cells(DC)to CD8^(+)T cells.1 However,antigen cross-presentation,which is fundamental in cancer cell elimination,is hindered in tumor DC by hyperglycosylation of the common saposin precursor prosaposin(pSAP)leading to impaired T cell tumor immunity-yet,the potential of recombinant pSAP to re-establish T cell responses may offer a novel way to counteract immune evasion in a therapeutic approach.
出处 《Signal Transduction and Targeted Therapy》 SCIE CSCD 2024年第8期3150-3152,共3页 信号转导与靶向治疗(英文)
关键词 IMPAIRED IMMUNITY al.
  • 相关文献

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部