摘要
In their article published in Nature,Peruzotti-Jametta et al.identify metabolic reprogramming of microglia as a defining characteristic of their persistent and harmful activation during inflammatory neurodegeneration,which is observable in conditions like multiple sclerosis(MS).Subsequently,the authors demonstrate how mitigating mitochondrial dysregulation in microglia alleviates disease progression in an animal model of MS,thereby unveiling a potential novel target for the treatment of MS(Fig.1).
基金
J.K.S's and C.M's research in MS is supported by the Werner Otto-Stiftung(07/100 and 08/104)
C.M.is funded by the Clinician Scientist Program of the University Medical Center Hamburg-Eppendorf.M.A.Fi's research into inflammation-induced neurodegeneration during MS at the Institute of Neuroimmunology and Multiple Sclerosis is supported by the Bundesministerium fur Bildung und Forschung(16GW0308K)
Deutsche Forschungsgemeinschaft(FR1720/25-1,FR1720/24-1,FR1720/11-2,FR1720/9-2,SFB1328 A16)
Gemeinnutzige Hertie-Stiftung(P1200091,P1210014,P1220064,P1230093)
Deutsche Multiple Sklerose Gesellschaft(V6.2)
Walter und Ilse Rose-Stiftung(T0298/38958/2021)
Research Funds of the University Medical Center Hamburg-Eppendorf.
