小脑经颅磁刺激技术在Alzheimer’s病认知康复中的研究进展

Research progress of cerebellar transcranial magnetic stimulation in cognitive rehabilitation of Alzheimer’s disease

Alzheimer’s病(AD)是以进行性认知功能障碍和行为损害为主要表现的神经退行性疾病,至今仍缺乏有效的药物治疗手段。经颅磁刺激(TMS)是一种非侵入性脑刺激技术,在改善和调节认知功能方面的作用日益凸显。以往TMS刺激的靶区集中在大脑皮质,但越来越多的研究表明,刺激小脑不仅可以调节大脑运动皮质区,并且对远隔的大脑认知相关脑区有调控和整合作用。因此,小脑已逐渐成为AD认知康复的非侵入性调控治疗潜在靶点。本文总结了小脑参与认知功能调控的解剖和功能基础以及小脑TMS调控认知功能的相关研究进展。

Alzheimer's disease(AD)is a neurodegenerative disease characterized by progressive cognitive dysfunction and behavioral impairment,with a lack of effective drug treatment.Transcranial magnetic stimulation(TMS)is a non-invasive brain stimulation technique,and its role in regulating and improving cognitive function has become increasingly prominent.Previously,the targets of TMS stimulation were focused on the cerebral cortices,but emerging evidence suggests that cerebellum stimulation could not only regulate the motor cortex but also regulate and integrate the distant cognitive-related cerebral regions.Consequently,the cerebellum has gradually emerged as a potential non-invasive therapeutic target for cognitive rehabilitation in AD.This article summarizes the anatomical and functional basis of the cerebellum's involvement in cognitive function regulation,as well as the research progress on TMS modulation of cognitive function mediated by the cerebellum.