新冠肺炎患者康复期复阳的相关危险因素分析

Analysis of risk factors related to a SARS-Cov-2 recurrence after therapy among patients with COVID-19

目的筛查新型冠状病毒肺炎(COVID-19)患者经治疗出院后复阳的相关危险因素。方法纳入2022年1月至2022年2月在天津市第一中心医院(水西院区)接受医学观察的320例康复期新型冠状病毒感染者。采集临床资料及实验室检验数据,根据患者新型冠状病毒(SARS-CoV-2)核酸复查是否阳性分为复阳组和未复阳组,并利用Logistic回归分析筛查部分患者复阳的相关危险因素。结果本研究纳入的320例患者中复阳73例,未复阳247例,复阳率为22.8%。Logistic回归分析显示,高CRP值(OR=1.050,95%CI:1.001~1.100;P=0.045)、既往慢性肝病史(OR=6.493,95%CI:2.771~15.216;P<0.01)是新型冠状病毒肺炎患者复阳的独立危险因素。结论感染新冠病毒后CRP值较高以及既往有慢性肝病史的患者存在较高的复阳风险,对该类患者更应做好预防及心理疏导。

Objective To explore the risk factors related to a severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)recurrence among coronavirus disease 2019(COVID-19)patients after therapy.Methods The clinical and laboratorial data of 320 patients with COVID-19 after therapy in Tianjin First Center Hospital from January 2022 to February 2022 were collected.Based on re-positive detection of SARS-CoV-2 RNA,the patients were divided into recurrence group and non-recurrence group.Logistic regression was used to further analyze risk factors related to a SARS-CoV-2 recurrence.Results The 320 patients were divided into recurrence group(n=73)and non-recurrence group(n=247),and the proportion of recurrence was 22.8%.Logistic regression analysis showed that higher CRP(OR=1.050,95%CI:1.001~1.100;P=0.045)and a history of chronic liver disease(OR=6.493,95%CI:2.771~15.216;P<0.01)were independent risk factors for a SARS-CoV-2 recurrence of patients with COVID-19 after therapy.Conclusion COVID-19 patients with higher CRP and a history of chronic liver disease were prone to a SARS-CoV-2 recurrence.Such patients should take preventive measures and psychological counseling.