复方异丙托溴铵联合普米克令舒对尘肺病大容量WLL围术期患者的疗效和安全性影响

Effect of compound ipratropium bromide combined with Pulmicort resuscitation on the efficacy and safety of pneumoconiosis patients with large volume WLL during perioperative period

目的探讨复方异丙托溴铵联合普米克令舒在尘肺病大容量全肺灌洗(WLL)的临床疗效。方法选取2018年1月至2019年4月在我院治疗的尘肺病患者94例,采用随机数字表法将患者随机分为观察组(n=46)和对照组(n=48),对照组给予大容量WLL治疗,观察组在对照组基础上给予复方异丙托溴铵联合普米克令舒,观察两组患者治疗前后肺功能、血气指标等。结果观察组治疗后用力肺活量(FVC)、第1秒用力呼气容积(FEV1)和FEV1/FVC明显高于对照组(P<0.05);观察组治疗后血氧分压(PaO2)明显高于对照组(P<0.05),而动脉血二氧化碳分压(PaCO_(2))明显低于对照组(P<0.05);观察组低氧血症、气道压增高发生率分别为13.04%和10.87%,明显低于对照组(P<0.05)。结论复方异丙托溴铵联合普米克令舒在尘肺病大容量WLL治疗中有较好的效果,值得临床使用。

Objective To investigate the clinical efficacy of compound ipratropium bromide combined with Pulmicort resuscitation in large volume whole lung lavage(WLL)for pneumoconiosis.Methods 94 pneumoconiosis patients treated in our hospital from January 2018 to April 2019 were selected,the patients were randomly divided into observation group(n=46)and control group(n=48),the control group was treated with large volume WLL,while the observation group was treated with compound ipratropium bromide combined with Pulmicort resuscitation on the basis of the control group,the pulmonary function and blood gas index and so on were observed before and after treatment in both groups.Results The forced lung volume(FVC),forced expiratory volume(FEV1)and FEV1/FVC in the observation group after treatment were significantly higher than those in the control group(P<0.05);The blood oxygen partial pressure(PaO_(2))in the observation group was significantly higher than that in the control group(P<0.05),while arterial blood carbon dioxide partial pressure(PaCO_(2))was significantly lower than the control group(P<0.05);The incidence of hypoxemia and airway pressure were 13.04%and 10.87%,respectively,significantly lower than the control group(P<0.05).Conclusion Compound ipratropium bromide combined with Pulmicort resuscitation has a good effect in the treatment of pneumoconiosis with large volume WLL,which is worthy of clinical use.