替罗非班对急性脑梗死取栓治疗病人血清细胞因子、神经功能及预后的影响

Effects of Tirofiban on Serum Cytokines,Neurological Function and Prognosis in Patients Underwent Thrombectomy for Acute Cerebral Infarction

目的探究替罗非班对急性脑梗死取栓治疗病人血清细胞因子、神经功能及预后的影响。方法研究2020年1月至2023年3月华中科技大学同济医学院附属武汉市中心医院收治的200例急性脑梗死取栓治疗患者的临床资料,根据其是否应用替罗非班治疗将取栓治疗后的患者分为替罗非班组(观察组,n=100)和非替罗非班组(对照组,n=100)。比较两组患者治疗前后的血清细胞因子相关指标[神经元特异性烯醇化酶(NSE)、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]、神经功能[美国国立卫生研究院卒中量表(NIHSS)评分]和预后情况[改良Rankin表(mRS)评分]。结果两组患者他们在治疗前血清细胞因子相关指标、神经功均无统计学差异(P>0.05),治疗后观察组血清NSE、IL-6、TNF-α的水平均较对照组有所减低(P<0.05)。观察组患者术后14d的NIHSS评分和术后3个月的mRS评分相较于对照组有所降低(P<0.05)。结论替罗非班可以改善经取栓治疗的急性脑梗死患者的神经功能、血小板功能及预后情况,降低炎性反应。

Objective To explore the effects of tirofiban on serum cytokines,neurological function and prognosis in patients underwent thrombectomy for acute cerebral infarction.Methods The clinical data of 200 patients underwent thrombectomy for acute cerebral infarction in Wuhan Central Hospital,affiliated to Tongji Medical College of Huazhong University of Science and Technology,from January 2020 to March 2023 were analyzed.Patients were classified into two groups according to the presence or absence of tirofiban therapy after surgery,observation group(n=100)and control group(n=100).Serum cytokine indicators[neuron specific enolase(NSE),interleukin-6(IL-6),and tumor necrosis factor-α(TNF-α)],neurological function[National Institutes of Health Stroke Scale(NIHSS)]and prognosis[Modified Rankin Scale(mRS)score]were compared between two groups.Results Serum cytokine indexes and neurological function parameters yielded no statistical difference between two groups before treatment(P>0.05).After treatment,observation group had lower NSE,IL-6 and TNF-αlevels than those of control group(P<0.05).Observation group scored lower on NIHSS at postoperative 14d and mRS at postoperative 3 months than control group(P<0.05).Conclusion Tirofiban for patients underwent thrombectomy for acute cerebral infarction can effectively improve neurological function,platelet function and prognosis,and attenuate the inflammatory response in patients.