腰痹康颗粒结合骨化三醇对脊柱骨折PVP术后的影响

Effect of Yaobikang Granule and calcitriol on ODI score and bone metabolism in patients with spinal fracture after PVP

目的探究腰痹康颗粒联合骨化三醇对脊柱骨折经皮椎体成形术(Percutaneous vertebroplasty,PVP)患者术后的影响。方法选择汝州市第一人民医院骨科2020年5月至2022年5月期间收治的86例脊柱骨折PVP术患者开展研究,按照随机抽签法分为对照组(n=43例)、观察组(n=43例),均接受常规术后对症治疗,其中对照组口服骨化三醇,观察组联合口服骨化三醇、腰痹康颗粒,对比临床疗效,包括骨代谢、腰椎功能、生活质量等。结果用药1个月后,观察组优良率较对照组高,差异有统计学意义(P<0.05);观察组血清BGP、PINP及β-CTX水平较对照组改善明显,差异有统计学意义(P<0.05);观察组ODI评分较对照组高,差异有统计学意义(P<0.05);观察组随访3个月GQOLI-74评分较对照组高,差异有统计学意义(P<0.05)。结论腰痹康颗粒结合骨化三醇的作用效果较明显,可调节术后患者骨代谢变化,改善腰椎功能,优化生活质量。

Objective To explore the effect of Yaobikang granule combined with calcitriol on patients with spinal fracture after percutaneous vertebroplasty(PVP).Methods 86 patients with PVP for spinal fracture admitted to the Department of Orthopedics of the First People′s Hospital of Ruzhou City from May 2020 to May 2022 were selected for the study.They were randomly divided into the control group(n=43 cases)and the observation group(n=43 cases)according to the method of drawing lots.All of them received routine postoperative symptomatic treatment.Among them,the control group took calcitriol orally,the observation group took calcitriol orally,and the observation group took Yaobikang granules orally to compare the clinical effects,including bone metabolism,lumbar function Quality of life,etc.Results After one month of medication,the excellent and good rate of the observation group was higher than that of the control group,with a statistically significant difference(P<0.05);Serum BGP,PINP andβ-The level of CTX was significantly improved compared with the control group(P<0.05);The ODI score of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05);The GQOLI-74 score in the observation group was significantly higher than that in the control group(P<0.05).Conclusion The effect of Yaobikang granule combined with calcitriol is obvious,which can adjust the changes of bone metabolism after operation,improve the lumbar function and optimize the quality of life.