草酸艾司西肽普兰治疗躯体形式障碍的效果观察

Effect of escitalopram oxalate in the treatment of somatoform disorder

目的探讨草酸艾司西肽普兰治疗躯体形式障碍的效果观察,方法选择2019年12月—2021年12月本院收治的躯体形式障碍患者98例,按照随机数字表法分为观察组(n=49)与对照组(n=49),观察组采取草酸艾司西肽普兰治疗,对照组采取盐酸阿米替林治疗,采用汉密尔顿焦虑(HAMA)、汉密尔顿抑郁(HAMD)及健康问卷躯体症状群(PHQ-15)量表比较两组治疗前与治疗后8周心理与躯体状况,再比较两组治疗后8周效果及药物不良反应。结果治疗后两组HAMA、HAMD、PHQ-15评分均降低,且观察组降低幅度更明显(P<0.05)。观察组总有效率85.71%(42/49)高于对照组总有效率67.34%(33/49)(P<0.05)。结论草酸艾司西肽普兰治疗躯体形式障碍的效果明显,能够缓解患者焦虑与抑郁情绪,改善患者躯体症状,促进疾病恢复,且药物不良反应少,具有安全性。

Objective To investigate the effect of escitalopram oxalate in the treatment of somatoform disorder.Methods Ninety-eight patients with somatoform disorder admitted to our hospital from December 2019 to December 2021 were selected and divided into an observation group(n=49)and a control group(n=49)according to random number table.The observation group was treated with escitalopram oxalate and the control group was treated with amitriptyline hydrochloride.Hamilton Anxiety Scale(HAMA),Hamilton Depression Scale(HAMD)and Health Questionnaire-15(PHQ-15)scales were used to compare the psychological and physical status of the two groups before treatment and 8 weeks after treatment,and then the effect and adverse drug reactions were compared between the two groups 8 weeks after treatment.Results The scores of HAMA,HAMD and PHQ-15 after treatment were lower than those before treatment,and the observation group was lower than the control group(P<0.05).The overall response rate was higher in the observation group than in the control group(P<0.05).Conclusion Escitalopram oxalate is effective and safe in the treatment of somatoform disorder.