吸入性沙丁胺醇联合小儿肺热咳喘颗粒对支气管肺炎患儿炎症因子及肺功能的影响

Effects of inhaled salbutamol combined with lung Heat Cough asthmatic Granules on inflammatory factors and lung function in children with bronchial pneumonia

目的探讨吸入性沙丁胺醇联合小儿肺热咳喘颗粒对支气管肺炎患儿炎症因子及肺功能的影响。方法选择2020年10月—2022年10月医院接诊的87例支气管肺炎患儿,用随机数字法分成对照组(43例)、观察组(44例)。对照组予沙丁胺醇雾化吸入治疗,在其基础上,观察组合用小儿肺热咳喘颗粒治疗,持续一周对比两组疗效、肺功能、炎症因子及不良反应情况。结果观察组总有效率(95.45%)较对照组的(79.07%)高,有统计学差异(P<0.05);两组治疗后用力肺活量(FVC)、最大呼吸峰流速(PEF)、第1s用力呼气容积(FEV1)水平均上升,且观察组以上肺功能指标较对照组更高,有统计学差异(P<0.05);两组治疗后C反应蛋白(CRP)、白介素-6(IL-6)及降钙素原(PCT)水平均降低,且观察组以上炎症因子水平较对照组更低,有统计学差异(P<0.05);两组不良反应率比,无统计学差异(P>0.05)。结论吸入性沙丁胺醇联合小儿肺热咳喘颗粒可降低支气管肺炎患儿炎症反应,改善肺功能,提高疗效,且安全性高。

Objective To investigate the effects of inhaled salbutamol combined with children′s lung heat Kechuan granules on inflammatory factors and lung function in children with bronchial pneumonia.Methods A total of 87 children with bronchopneumonia admitted to hospital from October 2020 to October 2022 were randomly divided into control group(43 cases)and observation group(44 cases).The control group was treated with salbutamol aerosol inhalation,on the basis of which,observation was made that the combination was treated with children′s lung heat cough asthma granules for a week.The efficacy,lung function,inflammatory factors and adverse reactions of the two groups were compared.Results The total effective rate of the observation group(95.45%)was higher than that of the control group(79.07%),with statistical difference(P<0.05).Forced vital capacity(FVC),maximum peak respiratory flow velocity(PEF)and 1s forced expiratory volume(FEV1)were all increased in both groups after treatment,and the above pulmonary function indexes in the observation group were higher than those in the control group,with statistical difference(P<0.05).After treatment,the levels of C-reactive protein(CRP),interleukin-6(IL-6)and procalcitonin(PCT)were decreased in both groups,and the levels of above inflammatory factors in the observation group were lower than those in the control group,with statistical difference(P<0.05).There was no significant difference in the ratio of adverse reaction between the two groups(P>0.05).Conclusion Inhaled salbutamol combined with children′s lung heat cough Chuan granules can reduce inflammatory response,improve lung function,improve efficacy,and high safety.