基于CiteSpace对酒精性肝病药物研究进展的知识图谱分析

Knowledge Mapping Analysis Based on CiteSpace for the Research Progress of Drugs for Alcoholic Liver Disease

目的 通过可视化分析酒精性肝病的研究现状和热点方向,为今后深入研究和临床应用提供指导。方法 分别检索CNKI和WOS数据库中2000—2023年收录的酒精性肝病研究文献,使用CiteSpace软件对研究国家、机构和作者合作情况系统分析,绘成关键词共现图、聚类图和突现性分析图。结果 经筛选,中英文文献年发文量均呈上升趋势。中国为发文量最多的国家。对中文文献分析发现:浙江中医药大学是频数最高的机构;陈芝芸是发文量最多的作者;频数最高的关键词为“大鼠”。对英文文献分析发现:萨洛尼卡大学是发文量最多的机构;Athyros、Vasilios G是发文量最多的作者。关键词多与发病机制有关。结论 酒精性肝病的发病机制尚未探明,通过现代技术阐释中药治疗酒精性肝病的机制为未来研究的方向。

Objective To analyze the current status and hot research directions of alcoholic liver disease(ALD)by visualization atlas,and to provide guidance for further research and clinical application.Methods we searched CNKI and WOS databases for alcohol-related liver diseases published in the 2023-2000 respectively.CiteSpace software is used to analyze the cooperation among countries,institutions and authors,and draw the keyword co-occurrence map,clustering map and emergent analysis map.Results after screening,the annual output of Chinese and English literature shows an upward trend.China is the country with the largest amount of literature.An analysis of Chinese literature shows that Zhejiang Chinese Medical University is the most frequently used organization,Chen Zhiyun is the most frequently used author,and the most frequently used keyword is“Rat”.An analysis of the English literature found that the University of Salonika in Greece was the institution with the largest number of publications,with Athyros,Vasilios G being the author with the largest number of publications.Most of the key words are related to pathogenesis.Conclusion the pathogenesis of alcoholic liver disease is mainly due to liver injury induced by oxidative stress.The traditional Chinese medicine and its related components are Panax Notoginseng,Hovenia dulcis thunb,resveratrol etc.