基于“心合小肠”探讨中医药调控肠道菌群治疗围绝经期失眠

Study on the Feasibility of Regulating Intestinal Flora by Traditional Chinese Medicine in Treating Perimenopausal Insomnia Based on the Theory of"Heart and Small Intestine"

围绝经期失眠是女性从生育期向老年期过渡过程中的常见病、多发病,其大多数表现为入睡困难、睡中易醒、醒后仍觉疲乏、注意力不集中等。目前西药主要通过服用镇静类药物达到治疗目的,而存在的药物依赖性及其他药物副作用不容小觑,文章查阅中国知网、PubMed等数据库近年来发表的相关文献,发现大量研究已经证实围绝经期失眠与肠道菌群存在很大的关联性,且也有研究报道中医药治疗围绝经期失眠的常用药、常用方是通过调节肠道菌群平衡来实现的。文章将“心合小肠”理论与围绝经期失眠、肠道菌群及其代谢产物对围绝经期失眠的影响等四方面理论研究联系起来,探讨中医药通过调控肠道菌群治疗围绝经期失眠的科学性。

Perimenopausal insomnia is a common and frequently-occurring disease in women's transition from fertility period to old age,most of which are manifested as difficulty in falling asleep,easy to wake up in sleep,fatigue after waking up,inattention and so on.At present,sedative drugs are mainly used to achieve the therapeutic purpose of western medicine,and drug dependence and other drug side effects should not be underestimated.By referring to relevant literature published in recent years on CNKI,PubMed and other databases,this paper found that a large number of studies have confirmed that perimenopausal insomnia has a strong correlation with intestinal flora.And there are also studies to report that traditional Chinese medicine treatment of perimenopausal insomnia common drugs,common prescriptions are achieved by regulating the balance of intestinal flora.Therefore,this article connects the theory of"heart and small intestine"with four theoretical studies on perimenopausal insomnia,the influence of intestinal flora and its metabolites on perimenopausal insomnia,and discusses the scientific nature of Traditional Chinese Medicine in treating perimenopausal insomnia by regulating intestinal flora.