中药干预氧化应激防治糖尿病肾病的研究进展

Research Progress of Chinese Medicine Intervening Oxidative Stress to Prevent Diabetic Nephropathy

糖尿病肾病(diabetic nephropathy,DN)是糖尿病最严重的微血管并发症之一,是终末期肾脏病(end stage redal disease,ERSD)的重要原因。研究表明,氧化应激与糖尿病肾病的重要发病机制之一,其导致的代谢紊乱、血流动力异常、炎症参与了糖尿病肾病发生发展的全过程。中药具有多靶点、多途径、低不良反应等特点,在治疗DN方面独具优势,大量研究证实中药可有效减少活性氧(ROS)的产生,抑制氧化应激,减轻肾足细胞损伤。该文综述了近五年中药单体及复方通过抑制氧化应激防治DN的研究进展,以期为DN的治疗提供新的思路和方法。

Diabetic nephropathy(DN)is one of the most serious microvascular complications of diabetes mellitus and an important cause of end-stage renal disease.Studies have shown that oxidative stress is associated with one of the important pathogenesis of diabetic nephropathy,and its resulting metabolic disorders,hemodynamic abnormalities,and inflammation are involved in the whole process of the development of diabetic nephropathy.Chinese medicine,with its multiple targets,multiple pathways and low toxic side effects,has unique advantages in the treatment of DN.A large number of studies have confirmed that Chinese medicine can effectively reduce the production of reactive oxygen species(ROS),inhibit oxidative stress and reduce renal foot cell damage.This paper reviews the research progress of Chinese medicine monomers and compounds in preventing DN by inhibiting oxidative stress in the past five years,with a view to providing new ideas and methods for the treatment of DN.