HIV/AIDS高脂血症患者抗逆转录病毒治疗6年后血脂血糖监测结果分析

Analysis of plasma lipid and blood glucose monitoring results after 6 years of antiretroviral therapy in patients with HIV/AIDS hyperlipidemia

目的了解甘肃省抗逆转录病毒治疗(ART)HIV/AIDS高脂血症患者后血脂、血糖代谢状况,为调整临床治疗策略提供依据。方法收集甘肃省甘南、临夏、天水和武威等4个市州2017年入组接受ART的18~65岁HIV/AIDS高脂血症患者2023年血脂、血糖状况,采用SPSS 25.0进行统计学分析,以P<0.05为差异有统计学意义。结果共监测400例HIV/AIDS高脂血症患者,2023年平均甘油三酯(4.01±3.37)mmol/L,平均总胆固醇(6.37±2.99)mmol/L,平均空腹血糖(6.71±2.72)mmol/L。男女患者甘油三酯、总胆固醇水平差异具有统计学意义(t=3.588、2.000,P均<0.05),各年龄段患者甘油三酯、总胆固醇、空腹血糖水平差异具有统计学意义(F=8.887、3.728、4.891,P均<0.05);不同CD4^(+)T淋巴细胞计数患者的甘油三酯、总胆固醇水平差异无统计学意义(F=2.069、1.865,P均>0.05)、空腹血糖水平差异具有统计学意义(F=4.062,P=0.018)。男女患者高胆固醇血症、高血糖占比差异具有统计学意义(χ^(2)=4.053、4.904,P均<0.05),各年龄段患者高胆固醇血症占比差异有统计学意义(χ^(2)=9.145,P=0.010);不同CD4^(+)T淋巴细胞计数患者高胆固醇血症占比差异具有统计学意义(χ^(2)=7.937,P=0.019)。结论甘肃省HIV/AIDS高脂血症患者接受ART后血脂异常主要以胆固醇升高为主,性别、年龄、CD4^(+)T淋巴细胞计数对其有一定的影响。

Objective To understand the metabolic status of blood lipid and blood glucose in HIV AIDS(human immunodeficiency virus/acquired immunodeficiency syndrome)hyperlipidemia patients after ART(antiretroviral therapy)in Gansu Province,and to provide basis for adjusting clinica treatment strategies.Methods The blood lipid and blood glucose data of HIV/AIDS hyperlipidemia patients aged 18-65 years who were enrolled to receive ART in 2017 in Gannan,Linxia,Tianshui,Wuwei in Gansu Province in 2023 were collected.Statistical analysis was performed by SPSS 25.0,and P<0.05 was considered as statistically significant.Results A total of 400 patients with HIV/AIDS hyperlipidemia were monitored.In 2023,the average triglyceride was(4.01±3.37)mmol/L,the average total cholesterol was(6.37±2.99)mmol/L,and the average fasting blood glucose was(6.71±2.72)mmol/L.The differences in triglyceride and total cholesterol levels between men and women were significant(t=3.588 and 2.000,respectively,P<0.05).There were significant differences in triglyceride,total cholesterol,and fasting blood glucose levels among patients of different age groups(F=8.887,3.728 and 4.891,respectively,P<0.05).There were no significant differences in triglyceride and total cholesterol levels among patients with different CD4^(+)T lymphocyte cell counts(F=2.069 and 1.865,respectively,P>0.05),but the differences in fasting blood glucose level was statistically significant(F=4.062,P=0.018).The difference in the proportion of hypercholesterolemia and hyperglycemia between men and women was statistically significant(χ^(2)=4.053 and 4.904,respectively,P<0.05).The proportion of hypercholesterolemia among patients of all ages was statistically significant(χ^(2)=9.145,P<0.05).The proportion of hypercholesterolemia in patients with different CD4^(+)T lymphocyte cell counts was statistically significant(χ^(2)=7.937,P=0.019).Conclusions The main dyslipidemia among HIV/AIDS hyperlipidemia patients after ART was cholesterol increase in Gansu Province.Gender,age and CD4^(+)T lymphocyte cell count had certain effects on it.