基于128层螺旋CT探究芪参丹芍颗粒加减对冠心病心绞痛患者左心功能的影响

Exploration on the effects of modified Qishen Danshao Granule on left ventricular function in patients with angina pectoris of coronary heart disease based on 128-slice spiral CT

目的:基于128层螺旋CT(MSCT)探究芪参丹芍颗粒加减对冠心病心绞痛患者左心功能的影响。方法:选取2020年6月~2022年6月确诊的92例冠心病心绞痛患者进行前瞻性研究,使用92个密封不透明信封进行简单随机化分组为对照组(46例,给予阿托伐他汀钙片治疗)和观察组(46例,在阿托伐他汀钙片+芪参丹芍颗粒加减治疗)。比较两组临床疗效及不良反应发生情况;观察两组治疗前后中医证候积分、血脂指标(TC、TG、LDL-C、HDL-C);采用128层MSCT评估两组患者治疗前后左心功能[舒张末期容积(EDV)、收缩末期容积(ESV)、每搏输出量(SV)、射血分数(EF)]。结果:与对照组治疗后比较,观察组治疗总有效率较高,中医证候积分较低,TC、TG、LDL-C指标较低,HDL-C指标较高,EDV、ESV指标较低,SV、EF指标较高,以上差异均有统计学意义(P<0.05);两组治疗期间不良反应发生率比较无明显差异(P>0.05)。结论:芪参丹芍颗粒加减治疗冠心病心绞痛效果显著,能够改善患者中医证候积分,改善血脂及心功能情况,且安全性良好。

Objective:To explore the effects of modified Qishen Danshao Granule on left ventricular function in patients with angina pectoris of coronary heart disease based on 128-slice spiral CT(MSCT).Methods:A prospective study was conducted on 114 patients with acute KOA who were confirmed and treated in the hospital were enrolled between June 2020 and June 2022.92 sealed opaque envelopes were used for simple randomization and divided into the control group(46 patients,atorvastatin calcium tablets)and observation group(46 cases,calcium tablets+Qishen Danshao Granules).The clinical curative effect and the occurrence of adverse reactions were compared between the two groups.The scores of TCM syndromes and levels of blood lipid indexes(TC,TG,LDL-C,HDL-C)in the two groups were observed before and after treatment.The left ventricular function indexes[end-diastolic volume(EDV),end-systolic volume(ESV),stroke volume(SV),ejection fraction(EF)]were evaluated by 128-slice MSCT.Results:Compared with the control group after treatment,the total effective rate of the observation group was higher,scores of TCM syndromes were lower,the TC,TG and LDL-C were lower,HDL-C was higher,the EDV and ESV were lower,and the SV and EF were higher,the above differences were statistically significant(P<0.05).The incidence of adverse reactions during treatment was similar between the two groups(P>0.05).Conclusion:The curative effect of modified Qishen Danshao Granule is significant on angina pectoris of coronary heart disease,which can improve TCM syndromes,blood lipid and cardiac function,with good safety.