滋肾扶阳健骨方对围绝经期骨质疏松症(肾阴阳虚型)疗效观察

Observation on the therapeutic effect of the nourishing kidney,nourishing yang,and strengthening bone formula on patients with perimenopausal osteoporosis(kidney yin yang deficiency type)

目的:探讨滋肾扶阳健骨方治疗围绝经期骨质疏松症(肾阴阳虚型)患者的临床效果。方法:选取2020年6月~2022年6月本院收治的92例围绝经期骨质疏松患者,将其随机分为观察组(n=46)和对照组(n=46)。对照组行西药常规碳酸钙D3片治疗,观察组在其基础上予以滋肾扶阳健骨方治疗。连续治疗3个月后,比较两组疗效;比较两组中医症候积分、骨密度、骨代谢变化;比较两组用药安全性。结果:连续治疗3个月后,观察组治疗总有效率为97.83%,高于对照组的86.96%(P<0.05);治疗后两组中医症候积分、Ⅰ型胶原C端肽及抗酒石酸酸性磷酸酶5b水平较治疗前均有降低,且观察组低于对照组(P<0.05),两组L_(1)-L_(4)腰椎骨密度、左侧股骨颈骨密度及骨特异性碱性磷酸酶水平较治疗前均有提升,且观察组高于对照组(P<0.05);两组间药物不良反应率差异无统计学意义(P>0.05)。结论:滋肾扶阳健骨方治疗围绝经期骨质疏松症(肾阴阳虚型)能有效提升实际治疗效果,缓解患者典型症状,同时改善机体骨代谢水平,增加骨密度,且不会增加用药风险,安全性较高。

Objective:To explore the clinical effect of the Zishen Fuyang Jiangu formula in the treatment of perimenopausal osteoporosis(kidney yin yang deficiency type)patients.Method:92 patients with perimenopausal osteoporosis admitted to our hospital from June 2020 to June 2022 were randomly divided into an observation group(n=46)and a control group(n=46).The control group was treated with conventional Western medicine calcium carbonate D3 tablets,while the observation group was treated with nourishing kidney,nourishing yang,and strengthening bone formula on the basis of it.After continuous treatment for 3 months,compare the efficacy of the two groups;Compare the TCM syndrome scores,bone density,and changes in bone metabolism between two groups;Compare the safety of medication between two groups.Result:After continuous treatment for 3 months,the total effective rate of the observation group was 97.83%,which was higher than the control group's 86.96%(P<0.05);After treatment,the TCM syndrome score,C-terminal peptide of type I collagen,and anti tartaric acid phosphatase 5b levels in both groups decreased compared to before treatment,and the observation group was lower than the control group(P<0.05).The bone density of the L1-L4 lumbar spine,left femoral neck,and bone specific alkaline phosphatase levels in both groups increased compared to before treatment,and the observation group was higher than the control group(P<0.05);There was no statistically significant difference in the incidence of adverse drug reactions between the two groups(P>0.05).Conclusion:The Zishen Fuyang Jiangu Formula can effectively improve the actual treatment effect of perimenopausal osteoporosis(Kidney Yin Yang Deficiency Type),alleviate typical symptoms of patients,improve bone metabolism levels,increase bone density,and does not increase medication risk,with high safety.