益痹汤联合调督理筋针法治疗腰椎间盘突出症的疗效及对血清PGE2、TXB2、IL-23水平的影响

Effect of Yibi Decoction combined with Acupuncture for Regulating Du Meridian and Tendons on lumbar disc herniation and its influence on serum levels of PGE2,TXB2 and IL-23

目的:探究益痹汤联合调督理筋针法治疗腰椎间盘突出症的疗效及对血清前列腺素E2(PGE2)、血栓素B2(TXB2)、白细胞介素-23(IL-23)水平的影响。方法:选取我院2022年3月~2024年1月期间收治的腰椎间盘突出症患者112例作为研究对象,通过随机数字表法将其分为西医组和中医组,各56例,西医组给予常规西药治疗,中医组采用益痹汤联合调督理筋针法治疗,比较两组临床治疗效果、治疗前后腰椎功能、中医证候积分及血清PGE2、TXB2、IL-23水平。结果:中医组临床总有效率96.43%,高于西医组的83.93%(P<0.05);与治疗前比较,治疗1月后两组ODI评分、中医证候积分降低,JOA评分升高,且中医组以上评分变化幅度较西医组更大(P<0.05);两组治疗后血清PGE2、TXB2、IL-23水平较治疗前均下降,且中医组上述指标均低于西医组(P<0.05)。结论:益痹汤联合调督理筋针法用于腰椎间盘突出症治疗,可以有效缓解患者临床症状,改善腰椎功能,调节机体炎症及疼痛介质水平,有利于提升临床疗效。

Objective:To explore the efficacy of Yibi Decoction combined with Acupuncture for Regulating Du Meridian and Tendons in the treatment of lumbar intervertebral disc herniation and its influence on the levels of serum prostaglandin E2(PGE2),thromboxane B2(TXB2)and interleukin-23(IL-23).Method:112 patients with lumbar disc herniation were selected as the study objects who were admitted to our hospital from March 2022 to January 2024.They were divided into Western medicine group(treated with conventional western medicine)and Chinese medicine group(treated with Yibi Decoction combined with Acupuncture for Regulating Du Meridian and Tendons)by random number table method,with 56 cases in each group.The clinical effect,lumbar function before and after treatment,TCM syndrome score and serum PGE2,TXB2 and IL-23 levels were compared between the two groups.Results:Compared with the Western group,the total effective rate of TCM group was higher significantly(83.93%vs 96.43%,P<0.05).Compared with before treatment,ODI score and TCM syndrome score of the two groups decreased,JOA score increased after 1 month of treatment,and the above score changes in the TCM group were greater than those in the western group significantly(P<0.05).Serum levels of PGE2,TXB2 and IL-23 in both groups after treatment were lower than those before treatment,and the above indexes in the Chinese medicine group were lower than those in the western medicine group significantly(P<0.05).Conclusion:Yibi Decoction combined with Acupuncture for Regulating Du Meridian and Tendons for the treatment of lumbar disc herniation can effectively relieve the clinical symptoms of patients,improve the function of lumbar spine,regulate the level of inflammation and pain mediators in the body,and improve the clinical efficacy.