猴头健胃灵片治疗慢性胃炎、消化性溃疡临床应用专家共识

Expert Consensus on Clinical Application of Houtou Jianweiling Tablets in Treatment of Chronic Gastritis and Peptic Ulcers

慢性胃炎、消化性溃疡是常见的上消化道疾病,临床均以胃脘疼痛或胃脘胀满为主要临床表现。猴头健胃灵片是临床广泛应用的治疗胃脘疼痛或胃脘胀满的中成药,治疗慢性胃炎、胃及十二指肠溃疡临床使用安全,疗效显著。该共识经中华中医药学会立项及审核公布,编制遵循“科学性、清晰性、逻辑一致性”原则,按照中华中医药学会中成药临床应用专家共识制定的技术方案开展工作,采用“文献研究”“专家访谈”“临床问卷调查法”“名义组法”等相结合的研究方法,经国内50余名中、西医临床与方法学、药学等多学科专家共同研制。该共识旨在明确猴头健胃灵片治疗慢性胃炎、消化性溃疡临床疗效,完善其适应证,补充其安全性问题。该共识针对临床一线调查总结的临床问题,对有证据支持的临床问题,通过建议评估制定评价证据分级系统(GRADE)进行循证评价形成推荐意见;对证据支持不充分临床问题,通过名义组法达成专家共识,形成“共识建议”。该共识对猴头健胃灵片适应证及临床疗效、用法用量、疗程等进行了推荐或建议,并完善了安全性信息。共识稿件在全国范围内进行征求意见和同行评议,完成质量评价、适用性评价及目标用户评价。该共识为猴头健胃灵片临床的合理用药提供参考。

Chronic gastritis and peptic ulcer are common upper gastrointestinal diseases,clinically characterized by epigastric pain or fullness.Houtou Jianweiling tablets are widely used Chinese patent medicines in the treatment of epigastric pain or fullness.It is safe and effective in the treatment of chronic gastritis,as well as gastric and duodenal ulcers.This consensus has been approved,reviewed,and published by the China Association of Chinese Medicine.It has been prepared in accordance with the principle of''scientificity,clarity,and logical consistency'',and work was carried out following the technical scheme formulated by the expert consensus on the clinical application of Chinese patent medicines from the China Association of Chinese Medicine.It has been jointly developed by more than 50 Chinese and Western medicine experts in the clinical,methodological,pharmaceutical,and other multi-disciplinary fields in China by using research methods such as literature research,expert interviews,clinical questionnaire surveys,and nominal grouping.This consensus aims to clarify the clinical efficacy of Houtou Jianweiling tablets in the treatment of chronic gastritis and peptic ulcers,improve their indications,and supplement their safety issues.This consensus aims to solve clinical issues summarized from frontline investigations.For clinical issues supported by evidence,a Grading of Recommendations Assessment,Development,and Evaluation(GRADE)system was developed through recommendation evaluation to form evidence-based recommendations.For clinical issues with insufficient evidence support,expert consensus can be reached through the nominal grouping method to form consensus recommendations.This consensus recommends the indications,clinical efficacy,usage and dosage,and treatment course of Houtou Jianweiling tablets and improves safety information.The consensus manuscript undergoes nationwide solicitation of opinions and peer review,completing the quality evaluation,applicability evaluation,and target user evaluation.This consensus provides a reference for the rational use of Houtou Jianweiling tablets in clinical practice.