HPV自采样法在宫颈癌筛查中的应用进展

Advances in HPV self-sampling for cervical cancer screening

宫颈癌是全球女性中第四大常见癌症,目前有多种筛查方法可供选择,与其他筛查方法相比,人乳头瘤病毒(HPV)的DNA检测被认为是最有效的技术。然而,发展中国家缺乏有组织的宫颈癌筛查计划和设施,导致HPV的有效筛查难以实施,从而延误病情预判,使宫颈癌高发。为提高宫颈癌筛查女性覆盖率,需要一种简单、省时、非侵入性的筛查方法。目前,越来越多的证据支持自我采样法(自采样法)作为初级HPV筛查替代方法的有效性和实用性,该文从阴道样本自我采集、初次排尿样本自我采集和月经血样本自我采集3个层面,对HPV自采样法在宫颈癌筛查中的应用进展进行综述。

Cervical cancer is the fourth most common cancer among women worldwide,and several screening methods are currently available,with DNA testing for human papillomavirus(HPV)considered to be the most effective technique compared to other screening methods.However,due to the lack of organized screening programs and facilities in developing countries,effective screening of cervical cancer is difficult to implement,thereby delaying disease prediction and contributing to the high incidence of cervical cancer.In order to improve cervical cancer screening coverage in women,a simple,time-saving and non-invasive screening method is needed.At present,more and more evidence supports the validity and practicability of self-sampling as an alternative method for primary HPV screening.In this paper,we reviewed the application progress of HPV self-sampling in cervical cancer screening from three aspects:vaginal self-collection,initial urine sample self-collection and menstrual blood sample self-collection.