巴戟天寡糖抗抑郁作用机制的研究进展

Research progress on the mechanism of action of Morinda officinalis oligosaccharides on depression

抑郁症是一种心理精神障碍疾病。近些年,全世界抑郁症发病率的不断升高,给社会带来沉重的经济负担。巴戟天寡糖(Morinda officinalis oligosaccharides,MOOs)是从中草药巴戟天中提取的活性物质,可以舒郁安神、补肾益智,同时对患者的认知障碍有一定的改善作用。本文基于抑郁症的假说机制,通过查阅现有的研究阐释MOOs与抑郁症之间的联系,提出MOOs通过调节单胺类神经递质水平、增强神经可塑性、调节HPA轴功能和细胞因子水平以及影响肠道菌群等机制改善抑郁症,为MOOs抗抑郁的研究提供新思路。

Depression is a psychosomatic disorder.The rising incidence rate of depression in recent years is placing a heavy economic burden on societies around the world.Morinda officinalis oligosaccharides(MOOs)are active substances extracted from the Chinese herb Morinda officinalis that can soothe depression and calm the mind,tonify the kidneys,and benefit the intellect,as well as improve cognitive disorders in patients to a certain extent.On the basis of the hypothesised pathological mechanism of depression,this study explains the link between MOOs and depression by reviewing existing studies.We propose that MOOs can improve depression through mechanisms that regulate the levels of monoamine neurotransmitters,enhance neuroplasticity,regulate the function of the HPA axis and levels of cytokines,and influence gut microbiota.This paper provides new ideas for research on the antidepressant effects of MOOs.