神经环路鉴定技术在中医药脑科学领域的应用

Application of neurocircuit identification technology in traditional Chinese medicine brain science

神经环路是由不同神经元组成的复杂网络,是大脑功能实现的物质载体。神经环路鉴定技术通过对特定神经环路的结构追踪及其活动操纵,研究其对脑功能的充分性和必要性,对理解脑疾病发病机制尤为关键。作为神经科学与脑科学领域的高新技术手段,近年来已被逐渐引入中医药领域基础研究。本综述系统性梳理神经环路鉴定技术的原理及其在中医药脑科学领域的应用研究进展,指出该领域后期发展方向应立足中医药特色整体观念和辨证论治展开设计。开展中医药多样化手段干预疾病的神经环路机制研究有助于促进中医药与现代脑科学的深度融合。

The neural circuit is the material carrier for the realization of brain function,consisting of a complex network of different neurons.Neural circuit identification technology tracks the structure and activity of specific neural circuits,to study their adequacy and necessity for brain function,which is crucial for understanding the pathogenesis of brain diseases.As a high-tech tool in the fields of neuroscience and brain science,neural circuit identification technology has been gradually introduced into basic traditional Chinese medicine(TCM)research in recent years.This systematic review considers the principles of neural circuit identification technology and progress in its application in the field of TCM neuroscience.We note that future developments in this field should be based on the overall concept of TCM characteristics and the design of syndrome differentiation and treatment.Further research on the neural circuit mechanisms of diverse method of TCM in diseases will help to promote the deep integration of TCM and modern neuroscience.