P16^(INK4a)与人乳头瘤病毒感染及宫颈上皮内瘤变进展的相关性

Correlation among P16^(INK4a) expression,human papilloma virus infection,and cervical intraepithelial neoplasia progression

目的探讨P16^(INK4a)与人乳头瘤病毒(HPV)感染及宫颈上皮内瘤变(CIN)的相关性。方法选取2020年2月至2023年5月在我院就诊的CIN患者197例(CIN组),其中CIN1患者62例,CIN2患者89例,CIN3患者46例;同时选取接受子宫全切除术且术后病理证实宫颈组织正常患者50例作为对照组;检测2组P16^(INK4a)表达及HPV感染情况。结果对照组P16^(INK4a)阳性表达率和HPV感染率(10.00%和0.00%)显著低于CIN组(72.08%和45.69%,P<0.05);CIN2和CIN3患者P16^(INK4a)阳性表达率(80.90%和91.30%)显著高于CIN1患者(45.16%,P<0.05)。CIN3患者HPV感染率(63.04%)高于CIN1、CIN2患者(33.87%和44.94%,P<0.05)。有HPV感染的CIN患者P16^(INK4a)阳性表达率(93.33%)显著高于无HPV感染的CIN患者(54.21%,P<0.05);HPV16/18感染患者P16^(INK4a)阳性表达率(100.00%)显著高于HPV31/33/53感染患者(85.00%,P<0.05);不同年龄、体重指数CIN患者P16^(INK4a)阳性表达率比较,差异无统计学意义(P>0.05)。结论CIN患者P16^(INK4a)表达率明显升高,且与病变程度相关,P16^(INK4a)表达与HPV感染有关。

Objective To explore the correlation among P16^(INK4a) expression,human papilloma virus(HPV)infection,and cervical intraepithelial neoplasia(CIN).Methods A total of 197 patients with CIN who visited our hospital between February 2020 and May 2023 were selected,including 62 with CIN1,89 with CIN2,and 46 with CIN3.At the same time,50 patients who underwent total hysterectomy and had normal cervical tissue confirmed by postoperative pathology were selected as the control group.P16^(INK4a) expression and HPV infection were detected in each patient.Results The positive P16^(INK4a) expression and HPV infection rates of the control group were 10.00%and 0.00%,respectively,significantly lower than those of patients with CIN(72.08%and 45.69%,respectively)(P<0.05).The positive P16^(INK4a) expression rates of patients with CIN2 and CIN3 were 80.90%and 91.30%,respectively,significantly higher than that of patients with CIN1(45.16%)(P<0.05).The HPV infection rate among patients with CIN3 was 63.04%,significantly higher than those of patients with CIN1(33.87%)and CIN2(44.94%)(P<0.05).The positive P16^(INK4a) expression rate of patients with CIN and HPV infection was 93.33%,significantly higher than that of patients with CIN but without HPV infection(54.21%)(P<0.05).The positive P16^(INK4a) expression rate of patients with HPV16/18 infection was 100.00%,significantly higher than that of patients with HPV31/33/53 infection(85.00%)(P<0.05).There was no statistically significant difference in the positive P16^(INK4a) expression rate among patients with CIN by clinical characteristics such as age and body mass index(P>0.05).Conclusion The P16^(INK4a) expression rate among patients with CIN is significantly increased and correlated with lesion degree and HPV infection status.