中国胰肾联合移植临床诊疗指南

Clinical guideline for diagnosis and treatment of combined pancreas and kidney transplantation in China

糖尿病是全球性疾病,而中国成人糖尿病患者数量位居世界第一。胰肾联合移植作为治疗终末期糖尿病肾病或糖尿病合并终末期肾病最有效的手段,在1型糖尿病和部分2型糖尿病患者中可获得同样的疗效。为了进一步实现胰肾联合移植临床诊治标准化,由中华医学会器官移植学分会组织器官移植学专家,制订《中国胰肾联合移植临床诊疗指南》,指南采用2009版牛津大学循证医学中心的证据分级与推荐强度标准制订,针对胰肾联合移植类型、适应证和禁忌证、供器官及受者评估、器官获取及修整、术式选择、并发症的诊治、受者随访等方面的32个关键临床问题,给出了较为详细的循证推荐,旨在通过循证指导临床实践,全面提升我国胰肾联合移植诊治水平。

Diabetes mellitus is a global disease,and China ranks first in the world in terms of the number of adults with diabetes mellitus.Combined pancreas and kidney transplantation,as the most effective treatment for end-stage diabetic nephropathy or diabetes mellitus combined with end-stage renal disease,can achieve the same therapeutic effect in patients with type 1 diabetes mellitus and some patients with type 2 diabetes mellitus.In order to further standardize the clinical diagnosis and treatment of combined pancreas and kidney transplantation,organ transplantation experts from the Branch of Organ Transplantation of Chinese Medical Association formulated the clinical guideline for diagnosis and treatment of combined pancreas and kidney transplantation in China,which is formulated by adopting the 2009 version of the Oxford Centre for Evidence-Based Medicine′s criteria for grading the evidence and the strength of the recommendation.The guideline provides detailed evidence-based recommendations on 32 key clinical issues,including type of combined pancreas and kidney transplantation,indications and contraindications,donor organ and recipient evaluation,organ procurement and repair,selection of surgical procedures,diagnosis and treatment of complications,and recipient follow-up,aiming at guiding the clinical practice through evidence-based guidance to comprehensively improve the diagnosis and treatment of combined pancreas and kidney transplantation in China.