摘要
Hematopoietic stem and progenitor cells(HsPCs)are a subset population of multi-potent cells with self-renewal capability and differentiation into all lineages of blood cells(Zhang and Liu,2024).HSPCs arise from the ventral wall of embryonic dorsal aorta,the hemogenic endothelium in the aorta-gonad-mesonephros(AGM)region,tightly controlled by epigenetic,transcriptional,and signaling networks(Wu and Hirschi,2021).However,how developmental hemogenic endothelium performs cell fate surveillances during HSPC emergence and efficiently eliminates them to avoid abnormal hematopoiesisremainselusive.
基金
supported by the National Key R&D Program of China(2018YFA0800203)
the National Natural Science Foundation of China(Distinguished Young Scholars 31925014,Key Program 32130033
General Program 31571505)
the Key Research Program of Frontier Sciences,Chinese。
