肺纤维化中力学信号转导的研究进展

Research advances in mechanistic signaling in pulmonary fibrosis

肺纤维化是一种复杂并且难以治疗的疾病,其特征是细胞外基质积聚和肺组织机械性能改变。生物力学特性与组织纤维化的发生、发展和治疗密切相关。本文总结了肺部生物力学微环境的变化,并重点介绍了机械转导在肺组织纤维化中的作用以及对靶向力学信号改善肺纤维化的最新临床研究进展。

Pulmonary fibrosis is a complex and intractable disease characterized by extracellular matrix accumulation and altered mechanical properties of lung tissue.Biomechanical properties are closely related to the development,progression,and treatment of tissue fibrosis.In this review,we summarized the changes in the pulmonary biomechanical microenvironment,highlight the role of mechanotransduction in pulmonary fibrosis,and describe recent clinical advances targeting mechanical signals to alleviate pulmonary fibrosis.