慢性胰腺炎临床研究的挑战与展望

Challenges and prospects for clinical research on chronic pancreatitis

慢性胰腺炎(chronic pancreatitis,CP)发病率与患病率逐年上升,已成为全球多数国家重要的医疗卫生问题。CP由遗传、环境等多因素共同致病,未来仍需深入探索相关致病基因与遗传致病机制。CP疼痛相关机制尚不明确,国外持续性疼痛较多,而国内患者以阵发性疼痛为主,内镜与外科手术在疼痛管理上的疗效比较有待进一步研究。CP患者普遍存在胰腺内外分泌功能受损,未来亟需优化胰腺内外分泌功能评估手段。CP是胰腺癌发生的重要危险因素,但是否应对CP患者进行胰腺癌相关筛查,目前仍存有争议。文章就CP临床研究领域的挑战与展望作一概述,为国内CP研究领域同行提供参考。

The incidence and prevalence of chronic pancreatitis(CP)are increasing year by year,and it has become an important medical and health problem in most countries around the world.CP is caused by multiple factors such as genetics and environment,and more than half of the patients in China are idiopathic CP,and it is still necessary to explore the related pathogenic genes and genetic pathogenic mechanisms in the future.The mechanism of CP related pain is still unclear,and there are many persistent pain in foreign countries,while paroxysmal pain is the main problem in domestic patients,and the efficacy of endoscopic and surgical surgery in pain management needs to be further studied.Monitoring of pancreatic endocrine function in patients with CP is crucial,and there is an urgent need to optimize the evaluation methods of pancreatic function in the future.CP is an important risk factor for pancreatic cancer,but whether patients with CP should be screened for pancreatic cancer is still controversial.This article provides an overview of the challenges and prospects in the field of CP clinical research and provides reference for domestic peers in the field of CP research.