慢性胰腺炎病因学研究进展

Advances in the etiology of chronic pancreatitis

慢性胰腺炎(chronic pancreatitis,CP)是一种胰腺组织的慢性进行性炎症性疾病。常见的CP病因包括饮酒、吸烟、遗传、自身免疫、高钙血症、高脂血症等,部分无法明确病因的患者称为特发性CP。饮酒是成年CP患者中最常见的病因,而在青少年中遗传性CP较为常见。CP病因构成在不同国家和地区间存在差异,西方国家及日本以酒精性CP为主,而我国超半数的患者为特发性CP。文章就CP病因学相关研究进展作一综述。

Chronic pancreatitis(CP)is a chronic,progressive inflammatory disease of pancreatic tissue.Common causes of CP include alcohol consumption,smoking,genetics,autoimmunity,hypercalcemia,hyperlipidemia,etc.,and some patients who cannot identify the cause are called idiopathic CP.Alcohol consumption is the most common cause in adults with CP,while hereditary CP is more common in adolescents.The etiological composition of CP varies among different countries and regions,with alcoholic CP being the main disease in Western countries and Japan,while more than half of the patients in China are idiopathic CP.This article reviews the research progress related to the etiology of CP.