慢性胰腺炎干细胞治疗研究进展

Advances in stem cell therapy in chronic pancreatitis

慢性胰腺炎(chronic pancreatitis,CP)的发病机制复杂,目前仍缺乏针对性的有效治疗方式。干细胞具有调节炎症和免疫反应、促进损伤组织修复和再生的能力,目前已在多个器官或组织中有所应用。近年来干细胞治疗在CP中越来越受重视,已有动物试验证明其在抗炎和抗纤维化方面有一定作用,但针对CP疼痛症状和糖尿病、胰腺外分泌功能不全等并发症治疗的研究仍未见报道。目前,CP领域干细胞的研究仅停留在细胞和动物阶段,尚未有临床试验开展。文章就CP中干细胞治疗在胰腺炎症和纤维化、腹痛、胰腺外分泌功能不全、糖尿病等方面的研究作一综述。

Chronic pancreatitis(CP)has a complex pathogenesis and still lacks a targeted and effective treatment.Stem cells have the ability to regulate inflammation and immune response,and promote repair and regeneration of damaged tissues,which have been applied in many organs or tissues.In recent years,stem cell therapy has received increasing attention in CP,and studies have demonstrated its role in anti-inflammation and anti-fibrosis.However,there is still a lack of research on the treatment of painful symptoms of CP and complications such as diabetes mellitus and pancreatic exocrine insufficiency.Currently,stem cell research in CP is only at the cellular and animal level,and no clinical trials have yet been performed.This paper summarizes the research progress of stem cell therapy in CP in pancreatic inflammation and fibrosis,abdominal pain,pancreatic exocrine insufficiency,and diabetes mellitus.