中医药基于TGF-β1/Smad信号通路治疗IgA肾病的研究进展

Research Progress of Traditional Chinese Medicine in Treating IgA Nephropathy Based on TGF-β1/Smad Signaling Pathway

免疫球蛋白A(IgA)肾病是一种最常见的肾小球肾炎,是导致终末期肾衰竭的主要原因之一。IgA肾病的发生、发展与肾脏纤维化的进展存在紧密的关联性,因此针对性治疗肾脏纤维化,对于延缓IgA肾病的进展有重大的意义。TGF-β1/Smad信号通路在肾脏纤维化的病理发展中发挥着重要的作用。近些年来,中医药在防治IgA肾病中有着独特的优势,为明确中医药调控TGF-β1/Smad信号通路来治疗IgA肾病作用靶标,文章借鉴了国内、国外近十余年的文献,借助中医药的研究,从中药单体、中药复方几个方面,对治疗IgA肾病的作用进行了系统化的研究,旨在为临床上防治IgA肾病提供有效的依据。

Immunoglobulin A(IgA)nephropathy is the most common form of glomerulonephritis and is one of the leading causes of end-stage renal failure.The occurrence and development of IgA nephropathy are closely related to the progress of renal fibrosis.Therefore,it is of great significance to treat renal fibrosis specifically for delaying the progress of IgA nephropathy.TGF-β1/Smad signaling pathway plays an important role in the pathological development of renal fibrosis.In recent years,traditional Chinese medicine(TCM)has a unique advantage in the prevention and treatment of IgA nephropathy.In order to clarify that target of TCM in regulating TGF-β1/Smad signal pathway to treat IgA nephropathy,this article refer to the literatures of domestic and foreign countries in recent ten years,with the help of TCM research,systematically studied the effect of TCM on IgA nephropathy from several aspects of TCM monomer and TCM compound,aiming to provide effective basis for clinical prevention and treatment of IgA nephropathy.