基于血水同病理论探讨当归芍药散治疗复发性流产血栓前状态

Exploration of the Treatment of Pre-thrombotic State of Recurrent Abortion with Danggui Shaoyao Powder(当归芍药散)Based on the Theory of Blood-water Homoeopathy

复发性流产(recurrent spontaneous abortion,RSA)是临床常见的异常妊娠疾病之一,对其病因的探究一直是生殖医学领域热点及难点。血栓前状态(prethrombolic state,PTS)是一种凝血和抗凝系统失调的病理状态。妊娠期血液处于高凝状态,故血栓前状态是复发性流产的重要病因之一。西医对此疾病治疗效果欠佳,故该病的治疗需结合中医手段,中西医结合是治疗该病大势所趋。“血水同病”是始于《黄帝内经》时期的经典理论,概括了“血”与“水”生理病理的相关性,为中医临床诊治提供了一种新思路。研究发现,“血水同病”与血栓前状态之间存在联系。当归芍药散的立方是基于“木郁土虚、水湿瘀滞”之病机,是“血水同治”的经典方剂。文章以此为中心进行阐述,探讨基于血水同病理论以当归芍药散治疗复发性流产血栓前状态,希冀为临床治疗相关疾病提供新思路。

Recurrent spontaneous abortion(RSA)is one of the common abnormal pregnancy diseases in clinic,and the investigation of its etiology has been a hot spot and difficult point in the field of reproductive medicine.Prethrombolic state(PTS)is a pathological process in which the hemostatic,coagulation and anticoagulation systems are dysregulated.During pregnancy,the blood is in a hypercoagulable state,so the prethrombotic state is one of the most important causes of recurrent miscarriage.Western medicine is not effective in treating this disease,so the treatment of this disease needs to be combined with the means of traditional Chinese medicine,and the combination of traditional Chinese medicine and Western medicine is a major trend in the treatment of this disease.“Blood and water are the same disease”is a classic theory that began in the period of Inner Canon of Huangdi,which summarizes the correlation between the physiology and pathology of“blood”and“water”,and provides a new way of thinking for the clinical diagnosis and treatment of Chinese medicine.It was found that there is a connection between“blood and water”and the pre-thrombotic state.Danggui Shaoyao Powder(当归芍药散)is a formula proposed by the sage of healing,and its formula is based on the disease mechanism of“wood-depressing and earth-deficient,and water-dampness stagnation”,which is a classic formula for the treatment of“blood and water in the same disease”.This article focuses on the treatment of pre-thrombotic state of recurrent miscarriage with Danggui Shaoyao Powder based on the theory of blood-water homoeopathy,with the hope of providing new ideas for the clinical treatment of related diseases.