CEACAM1在代谢功能障碍相关脂肪性肝病中的作用

The Role of CEACAM1 in Metabolic Dysfunction⁃associated Steatotic Liver Disease

癌胚抗原相关细胞黏附分子1(carcinoembryonic antigen⁃related cell adhesion molecule 1,CEACAM1)是一种免疫球蛋白超家族的跨膜蛋白,参与介导细胞黏附、组织转移、免疫反应控制以及机体代谢平衡。研究表明,CEACAM1主要通过促进胰岛素清除以防止脂肪沉积,从而对肝脏发挥保护作用。CEACAM1表达水平下调会导致胰岛素抵抗状态发生恶性循环并加重代谢紊乱。由于CEACAM1在控制代谢功能障碍相关脂肪性肝病(metabolic dysfunction⁃associated steatotic liver disease,MASLD)中的关键地位,刺激其作用途径或调节其表达水平有望成为MASLD的治疗新方法。本文就CEACAM1在MASLD中的有关研究进展作一综述。

Carcinoembryonic antigen⁃related cell adhesion molecule 1(CEACAM1),a transmembrane protein of the immunoglobulin superfamily,is involved in mediating cell adhesion,tissue metastasis,control of immune response,and metabolic homeostasis.Studies have shown that CEACAM1 protects the liver by promoting insulin clearance and preventing fat deposition.The down⁃regulation of the CEACAM1 expression level leads to a vicious cycle of insulin resistance and aggravates metabolic disorders.As CEACAM1 is critical in con⁃trolling metabolic dysfunction⁃associated steatotic liver disease(MASLD),stimulating its pathway or regulating its expression level might be a potential new therapeutic approach for MASLD.In this paper,therefore,we summarize the research progress of CEACAM1 in MASLD.