lncRNA PVT1在心血管疾病中的研究进展

Research progress of lncRNA PVT1 in cardiovascular diseases

心血管疾病是全球范围内导致死亡和健康负担的主要原因之一,严重影响患者的生活质量,寻求早期识别、诊断和有效治疗方法至关重要。当前已有研究表明,长链非编码RNA(lncRNA)通过内源竞争RNA(ceRNA)参与肿瘤、心脑血管疾病、免疫性疾病的调控。其中lncRNA浆细胞瘤多样异位基因1(PVT1)通过促进纤维化增殖、炎症、细胞凋亡、线粒体代谢等途径加重心脏损伤,可能成为重要的检测及治疗靶点。由于目前研究较为零散,部分研究结论也存在差异,该文就lncRNA PVT1在心血管疾病中最新研究进展进行了综述,以期为心血管疾病的基础研究和临床实践提供更为全面的理论依据。

Cardiovascular disease is one of the leading causes of death and health burden worldwide,seriously affects the life quality of the patients.Therefore,it is essential to seek early identification,diagnosis and effective treatment method.At present,a large number of studies have shown that lncRNA is involved in the regulation of tumors,cardiocerebrovascular diseases and immune diseases through ceRNA and other mechanisms.Among them,lncRNA plasmacytoma variant translocation gene 1(PVT1)may become an important detection and therapeutic target by promoting fibrosis proliferation,inflammation,apoptosis,mitochondrial metabolism and other pathways to aggravate cardiac damage.However,the current research is scattered,and some of the research conclusions are different.Therefore,this article reviewed the latest research progress of lncRNA PVT1 in cardiovascular diseases,in order to provide a more comprehensive theoretical basis for basic research and clinical practice of cardiovascular diseases.