卡贝缩宫素联合缩宫素治疗宫缩乏力性产后出血患者的效果

Effects of Carbetocin combined with Oxytocin in treatment of patients with postpartum hemorrhage due to uterine inertia

目的:观察卡贝缩宫素联合缩宫素治疗宫缩乏力性产后出血患者的效果。方法:回顾性分析2022年5月至2024年3月该院收治的78例宫缩乏力性产后出血患者的临床资料,根据治疗方法不同将其分为对照组与观察组各39例。对照组采用缩宫素治疗,观察组在对照组基础上联合卡贝缩宫素治疗,比较两组临床疗效,治疗前后子宫收缩指标(子宫收缩强度、子宫收缩持续时间)、子宫动脉血流动力学指标(子宫动脉搏动指数、阻力指数、收缩期峰值流速)水平,完全止血时间,以及不良反应发生率。结果:观察组治疗总有效率为94.87%(37/39),高于对照组的79.49%(31/39),差异有统计学意义(P<0.05);治疗后,观察组子宫收缩强度大于对照组,子宫收缩持续时间长于对照组,差异均有统计学意义(P<0.05);治疗后,观察组子宫动脉搏动指数、阻力指数低于对照组,收缩期峰值流速高于对照组,差异均有统计学意义(P<0.05);观察组完全止血时间短于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:卡贝缩宫素联合缩宫素治疗宫缩乏力性产后出血患者可提高治疗总有效率,增大子宫收缩强度,延长子宫收缩持续时间,缩短完全止血时间,改善子宫动脉血流动力学指标水平,效果优于单纯缩宫素治疗。

Objective:To observe effects of Carbetocin combined with Oxytocin in treatment of patients with postpartum hemorrhage due to uterine inertia.Methods:The clinical data of 78 patients with postpartum hemorrhage caused by uterine inertia admitted to this hospital from May 2022 to March 2024 were retrospectively analyzed.According to different treatment methods,they were divided into control group and observation group,39 cases in each group.The control group was treated with Oxytocin,while the observation group was treated with Carbetocin on the basis of that of the control group.The clinical efficacy,the levels of uterine contraction indexes(uterine contraction intensity,uterine contraction duration),and the uterine artery hemodynamics indexes(uterine artery pulsation index,resistance index,peak systolic velocity)before and after the treatment,the complete hemostasis time,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 94.87%(37/39),which was higher than 79.49%(31/39)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the uterine contraction intensity in the observation group was greater than that in the control group,the uterine contraction duration was longer than that in the control group,and the differences were statistically significant(P<0.05).After the treatment,the uterine artery pulsation index and resistance index levels in the observation group were lower than those in the control group,the peak systolic velocity of uterine artery was higher than that in the control group,and the differences were statistically significant(P<0.05).The complete hemostasis time of the observation group was shorter than that of the control group,and the difference was statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Carbetocin combined with Oxytocin in the treatment of the patients with postpartum hemorrhage can improve the total effective rate of treatment,increase the uterine contraction intensity,prolong the uterine contraction duration,shorten the complete hemostasis time,and improve the levels of uterine artery hemodynamics.Moreover,it is superior to simple Oxytocin treatment.