SUA、hs-CRP水平联合Tan评分对急性脑梗死静脉溶栓患者再发卒中的预测价值

Predictive value of SUA and hs-CRP levels combined with Tan score for recurrent stroke in patients with acute cerebral infarction after intravenous thrombolysis

目的:探讨血尿酸(SUA)、超敏C反应蛋白(hs-CRP)水平联合CT血管造影(CTA)脑侧支循环(Tan)评分对急性脑梗死静脉溶栓患者再发卒中的预测价值。方法:回顾性分析2021年1月至2022年6月于该院接受静脉溶栓治疗的126例急性脑梗死患者的临床资料,出院后随访12个月,根据患者是否再发卒中将其分为再发组和未发组。比较两组SUA、hs-CRP水平和Tan评分,并采用受试者工作特征(ROC)曲线分析三者单独及联合检测对急性脑梗死静脉溶栓患者再发卒中的预测价值。结果:126例急性脑梗死患者经静脉溶栓治疗后,31例再发卒中,再发率为24.60%(31/126);再发组SUA、hs-CRP水平均高于未发组,Tan评分低于未发组,差异有统计学意义(P<0.05);ROC曲线分析结果显示,SUA、hs-CRP水平及Tan评分单项及联合检测预测急性脑梗死静脉溶栓患者再发卒中的曲线下面积分别为0.833、0.824、0.756、0.935,联合检测的预测价值最高,高于三者单项检测预测。结论:SUA、hs-CRP水平联合Tan评分对急性脑梗死静脉溶栓患者再发卒中的预测价值高于三者单项检测预测。

Objective:To investigate predictive value of serum uric acid(SUA)and high-sensitivity C-reactive protein(hs-CRP)levels combined with CT angiography(CTA)cerebral collateral circulation(Tan)score for recurrent stroke in patients with acute cerebral infarction after intravenous thrombolysis.Methods:The clinical data of 126 patients with acute cerebral infarction who received intravenous thrombolysis in this hospital from January 2021 to June 2022 were retrospectively analyzed.These patients were followed up for 12 months after discharge.Then,these patients were divided into recurrent group and non-recurrent group according to whether they had recurrent stroke.The levels of SUA and hs-CRP as well as the Tan score were compared between the two groups.The receiver operating characteristic(ROC)curve was used to analyze their predictive value single and combined detection of three indicators for recurrent stroke in the patients with acute cerebral infarction treated with intravenous thrombolysis.Results:After intravenous thrombolytic therapy in the 126 patients with acute cerebral infarction,31 patients had recurrent stroke,with a recurrence rate of 24.60%(31/126).The levels of SUA and hs-CRP in the recurrent group were higher than those in the non-recurrent group,the Tan score was lower than that in the non-recurrent group,and the differences were statistically significant(P<0.05).ROC curve analysis showed that the area under the curve of single and combined detection of SUA and hs-CRP levels and Tan score in the prediction of recurrent stroke in the patients with acute cerebral infarction after intravenous thrombolysis were 0.833,0.824,0.756 and 0.935,respectively.The predictive value of combined detection was the highest,which was higher than that of single detection.Conclusions:The predictive value of SUA and hs-CRP levels combined with Tan score for recurrent stroke in the patients with acute cerebral infarction after intravenous thrombolysis is higher than that of the three single tests.