老年肺腺癌病人术前全身免疫炎症指数/血清白蛋白与临床病理特征的相关性研究

Correlation between preoperative SII/ALB and clinicopathologic features in elderly patients with lung adenocarcinoma

目的 探讨术前全身免疫炎症指数/血清白蛋白(SII/ALB)与老年肺腺癌病人临床病理特征的相关性。方法 回顾性分析2020年1月至2023年6月于南京医科大学附属老年医院接受胸腔镜手术治疗的103例老年肺腺癌病人的临床病理资料,根据术前检验结果计算出SII/ALB值,以SII/ALB中位数将病人分为高SII/ALB组和低SII/ALB组,分析2组病人临床病理特征的差异。结果 103例老年肺腺癌病人的SII/ALB中位数为16.1,低SII/ALB组(SII/ALB≤16.1)47例,高SII/ALB组(SII/ALB>16.1)56例。2组间BMI、高级别腺癌成分、胸膜侵犯、TNM分期、淋巴结转移、气道播散比例比较,差异均有统计学意义(P<0.05);相关分析结果显示,SII/ALB水平与TNM分期、淋巴结转移相关(P<0.05)。结论 SII/ALB反映了肿瘤病人的免疫、炎症以及营养三方面状态。SII/ALB水平与TNM分期、淋巴结转移相关,监测SII/ALB水平有助于为老年肺腺癌的临床诊疗提供一定的参考信息。

Objective To investigate the correlation between preoperative systemic immunoinflammatory index/serum albumin(SII/ALB)and clinicopathological features in the elderly patients with lung adenocarcinoma.Methods The clinicopathological data of 103 elderly patients with lung adenocarcinoma treated by thoracoscopic surgery in Geriatric Hospital of Nanjing Medical University from January 2020 to June 2023 were retrospectively analyzed.SII/ALB value was calculated according to preoperative test results,and the patients were divided into high SII/ALB group and low SII/ALB group according to the median SII/ALB value.The relationship between SII/ALB and clinicopathological features of the patients was analyzed.Results The median SII/ALB was 16.1,and there were 47 cases in low SII/ALB group(SII/ALB≤16.1)and 56 cases in high SII/ALB group(SII/ALB>16.1).There were significant differences in BMI,high-grade adenocarcinoma components,pleural invasion,TNM stage,lymph node metastasis and airway spread between the two groups(P<0.05).The level of SII/ALB was correlated with TNM stage and lymph node metastasis(P<0.05).Conclusions SII/ALB reflects the immune,inflammatory and nutritional status of the patients.SII/ALB level is related to TNM stage and lymph node metastasis.Monitoring SII/ALB level is helpful to provide certain reference information for the clinical diagnosis and treatment of elderly lung adenocarcinoma.