阿尔茨海默病的DNA甲基化特征研究进展

Research progress on DNA methylation characteristics in Alzheimer′s disease

阿尔茨海默病(AD)是一种最常见的神经退行性疾病,目前仍缺乏有效治疗方法。识别分子生物标志物成为AD诊断和预防的关键。该文重点综述了DNA甲基化对AD病理的影响,并讨论了甲基化调节AD发生和发展的潜在作用。最后,通过检测AD患者血液样本中的DNA甲基化特征,为AD的早期筛查提供新的思路和策略。

Alzheimer′s disease(AD)is the most common neurodegenerative disorder,and effective treatments are still lacking.Identifying molecular biomarkers has become crucial for AD diagnosis and prevention.This article focuses on reviewing the impact of DNA methylation on AD pathology and discusses the potential role of methylation in regulating the onset and progression of AD.Finally,by examining characteristics of DNA methylation in blood samples from AD patients,aiming to provide new insights and strategies for early screening of AD.