NLR、FIB、CA199在子宫内膜异位症中评估分析

Evaluation and Analysis of NLR,FIB and CA199 in Endometriosis

目的:探讨中性粒细胞/淋巴细胞比值(NLR)、纤维蛋白原(FIB)、糖类抗原199(CA199)在子宫内膜异位症(EMT)中的评估价值。方法:选取2021年8月—2022年8月鄂州二医院收治的200例经手术病理确诊为EMT的患者作为研究对象纳入观察组,另选取同期140例健康体检者作为对照组。两组患者均接受实验室检查,对比两组患者血清NLR、FIB、CA199水平差异情况,以病理检查结果作为“金标准”,运用受试者工作特征曲线(ROC)分析NLR、FIB、CA199在EMT中的评估价值。结果:观察组NLR、FIB、CA199水平均显著高于对照组,差异有统计学意义(t=3.822、5.001、31.696,P<0.05);不同病理分期EMT患者NLR、FIB、CA199水平由高到低依次为Ⅳ期>Ⅲ期>Ⅱ期>Ⅰ期,差异有统计学意义(F=125.983、27.848、310.947,P<0.05)。ROC曲线分析显示,NLR、FIB、CA199联合诊断EMT的曲线下面积(AUC)为0.854,显著高于各项指标单独检测(0.627、0.659、0.826),差异有统计学意义(P<0.05)。结论:NLR、FIB、CA199在EMT患者中表达水平较高,对于EMT具有较好的评估价值。

Objective:To investigate the value of neutrophil/lymphocyte ratio(NLR),fibrinogen(FIB)and carbohydrate antigen 199(CA199)in the diagnosis of endometriosis(EMT).Methods:200 patients diagnosed with EMT through surgery and pathology admitted to Ezhou Second Hospital from August 2021 to August 2022 were included in the observation group as the study subjects,and 140 healthy subjects were selected as the control group.The differences of serum NLR,FIB and CA199 levels between the two groups were compared.The pathological examination results were used as the“gold standard”.The evaluation value of NLR,FIB and CA199 in EMT were analyzed with receiver operating characteristic curve(ROC).Results:The levels of NLR,FIB and CA199 in the observation group were significantly higher than those in the control group,and the difference was statistically significant(t=3.822,5.001,31.696;P<0.05).The levels of NLR,FIB and CA199 in different pathological stages of EMT were in the order of stageⅣ>stageⅢ>stageⅡ>stageⅠ,and the difference was statistically significant(F=125.983,27.848,310.947;P<0.05).ROC analysis showed that the area under the curve(AUC)of NLR,FIB and CA199 in the diagnosis of EMT was 0.854,which was significantly higher than that of each index(0.627,0.659 and 0.826),and the difference was statistically significant(P<0.05).Conclusion:NLR,FIB and CA199 are highly expressed in patients with endometriosis,and they are valuable in the evaluation of EMT.