低分子肝素钠联合气压治疗仪预防产后下肢静脉血栓的应用研究

Application of Low Molecular Weight Heparin Sodium Combined with Pneumatic Therapeutic Apparatus in the Prevention of Postpartum Lower Limb Venous Thrombosis

目的:观察低分子肝素钠联合气压治疗仪预防产后下肢静脉血栓(DVT)的应用研究。方法:选取2020年1月—2022年12月新余市妇幼保健院收治的102例存在血液高凝状态的产妇作为研究对象,按随机数表法将其分为对照组和观察组,每组各51例。对照组患者给予DVT基础预防处理和早期活动疗法,并在此基础上给予低分子肝素钠注射液治疗,观察组患者在对照组的基础上联合气压治疗仪治疗,两组患者均连续治疗1周。比较两组患者临床疗效、DVT及并发症发生情况、凝血功能指标[凝血酶时间(TT)、活化部分凝血活酶时间(APTT)、D-二聚体(D-D)、凝血酶原时间(PT)、纤维蛋白原(FIB)]、股静脉血流情况和不良反应。结果:观察组患者治疗总有效率高于对照组,差异有统计学意义(χ^(2)=4.993,P<0.05);观察组患者治疗后DVT及并发症发生情况低于对照组,差异有统计学意义(χ^(2)=7.141,P<0.05);两组患者治疗后凝血功能指标均改善,且观察组患者APTT、PT、TT水平高于对照组,FIB、D-D水平低于对照组,差异有统计学意义(t=7.524、8.140、6.270、9.552、9.980,P<0.05);观察组患者治疗后股静脉血流高峰和平均速度均高于对照组,差异有统计学意义(t=15.353、20.819,P<0.05)。结论:低分子肝素钠联合气压治疗仪预防产后DVT效果明显,可改善患者凝血功能,促进其下肢血液循环,利于其身体机能恢复,提高治疗效果,且安全性较高。

Objective:To observe the application of low molecular weight heparin sodium combined with pneumatic therapy in the prevention of postpartum lower limb venous thrombosis(DVT).Methods:According to the random number table method,102 postpartum women with hypercoagulable blood status admitted to the hospital from January 2020 to December 2022 were divided into control group and observation group,with 51 cases in each group.The control group was treated with DVT basic prevention treatment and early activity therapy,and on this basis,low molecular weight heparin sodium injection was given.The observation group was treated with a combination of pneumatic therapy equipment on the basis of the control group,and both groups were treated continuously for one week.The clinical efficacy,DVT and complications,coagulation function indexes[thrombin time(TT),active partial coagulation factor time(APTT),D-dimer(D-D),Prothrombin time(PT),fibrinogen(FIB)],femoral vein blood flow and adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the observation group was higher than that in the control group(χ^(2)=4.993,P<0.05).The incidence of DVT and complications in the observation group after treatment was lower than that in the control group(χ^(2)=7.141,P<0.05).After treatment,the coagulation function indicators of both groups of patients improved,and the levels of APTT,PT,TT in the observation group were higher than those in the control group,while the levels of FIB and D-D were lower than those in the control group(t=7.524,8.140,6.270,9.552,9.980;P<0.05).After treatment,the peak and average velocity of femoral vein blood flow in the observation group were higher than those in the control group(t=15.353,20.819;P<0.05).Conclusion:The combination of low molecular weight heparin sodium and pneumatic therapy has significant effect on preventing postpartum DVT,which is beneficial for improving maternal coagulation function,promoting lower limb blood circulation,promoting patient physical function recovery,improving treatment effectiveness,and having high safety.