120例宫颈高级别鳞状上皮内病变患者HPV感染特点及高危HPV阴性的筛查特征研究

Study on HPV Infection Characteristics and High-risk HPV Negative Screening Characteristics in 120 Patients with High-grade Squamous Intraepithelial Lesions of the Cervix

目的:分析宫颈高级别鳞状上皮内病变患者人乳头瘤病毒(HPV)感染特点及高危HPV阴性的筛查特征。方法:选取2020年1月—2022年10月安阳市妇幼保健院收治的120例宫颈高级别鳞状上皮内病变患者作为研究对象,所有患者均接受高危型HPV、液基薄层细胞学检查,对比分析两种方式的检测结果。结果:120例宫颈高级别鳞状上皮内病变患者经HPV检查显示有110例阳性,阳性率为91.67%,以单一感染居多,多重感染较少,高危型HPV阴性患者中液基薄层细胞学检查高于不能明确意义的非典型鳞状细胞有7例,占比70.0%,1例宫颈液基细胞学为非典型鳞状细胞和2例宫颈液基细胞学低于非典型鳞状细胞的均因临床症状转诊阴道镜。结论:宫颈高级别鳞状上皮内病变患者中HPV感染以高危型HPV感染及单一型感染居多。高危型HPV和宫颈液基细胞学联合筛查的阳性率最高。高危型HPV阴性的宫颈高级别鳞状上皮内病变患者往往没有显著的临床症状和宫颈液基细胞学异常。

Objective:To analyze the characteristics of HPV infection and screening characteristics of high-risk HPV negative cases in patients with high-grade squamous intraepithelial lesions of the cervix.Methods:120 patients with high-grade squamous intraepithelial lesions of the cervix were selected from the hospital from January 2020 to October 2022.All patients underwent high-risk HPV and liquid based thin layer cytology examinations,and the detection results of the two methods were compared and analyzed.Results:120 patients with high-grade squamous intraepithelial lesions of the cervix were tested positive for HPV,with 110 positive cases,and the positive rate was 91.67%.Single infection was more common,and multiple infections were less common.Among high-risk HPV negative patients,there were 7 cases(70.0%)with liquid based thin layer cytology examination higher than atypical squamous cells.1 case with atypical squamous cells in cervical liquid based cytology and 2 cases with lower cervical liquid based cytology than atypical squamous cells were referred to colposcopy due to clinical symptoms.Conclusion:In patients with high-grade squamous intraepithelial lesions of the cervix,HPV infection is mainly caused by high-risk HPV infection and single type infection.The combined screening of high-risk HPV and cervical liquid-based cytology has the highest positive rate.Patients with high-risk HPV negative cervical high-grade squamous intraepithelial lesions do not often have significant clinical symptoms or cervical liquid-based cytological abnormalities.