佳木斯传染病医院2021—2022年HBV感染筛查情况分析

Analysis of HBV Infection Screening in Jiamusi Infectious Disease Hospital from 2021 to 2022

目的:分析某三级甲等传染病专科医院乙型肝炎病毒(HBV)筛查情况。方法:回顾性分析2021年3月—2022年3月佳木斯市传染病医院进行乙型肝炎表明抗原(HBsAg)和普敏HBV DNA检测的1509例患者信息。收集报告HBsAg+/普敏HBV DNA-患者样本以及HBsAg-/普敏HBV DNA-但其他检查指标指向HBV感染的患者血清,采用高敏HBV DNA进行检测,并对患者HBV感染情况以及其他临床检查结果进行追踪。结果:1509例患者中有2例(0.13%)患者HBsAg+/普敏HBV DNA-,高敏HBV DNA检查结果为阳性,4例(0.26%)患者HBsAg-/普敏HBV DNA-,高敏HBV DNA检查结果为阳性。6例高敏HBV DNA检查均值(1.11±0.16 log10 IU/mL);HBsAg与普敏HBV DNA检查在入院筛查应用上具有相同等效性。结论:目前采用HBsAg作为判断患者HBV感染的依据,但依然有0.26%HBV DNA阳性的感染者,高于佳木斯地区一般人群HBsAg-/HBV DNA+(26/31720,0.08%)感染者比例,应采用高灵敏度试剂进行HBV DNA检测,以避免漏检。

Objective:To analyze the HBV screening in a tertiary first-class infectious disease hospital.Methods:HBsAg and Pumin HBV DNA of 1509 patients who visited Jiamusi Infectious Disease Hospital from March 2021 to March 2022 were tested.HBsAg+/Pumin HBV DNA-patient samples and HBsAg-/Pumin HBV DNA-but other test indicators pointing to the serum of patients infected with HBV infection were collected and reported.High-sensitivity HBV DNA was tested,and the patient’s HBV infection and other clinical test results were tracked.Results:Among 1509 patients,2 patients(0.13%)had HBsAg+/Pumin HBV DNA-,the high-sensitivity HBV DNA test result was positive,4 patients(0.26%)had HBsAg-/Pumin HBV DNA-,and the hypersensitive HBV DNA test result was positive.And the average value of 6 cases of high-sensitivity HBV DNA examination was(1.11±0.16 log10 IU/mL).HBsAg had the same equivalence as Pumin HBV DNA examination in admission screening application.Conclusion:At present,HBsAg is used as the basis for judging patients’HBV infection,but there are still 0.26%of HBV DNA-positive infections,which is higher than the proportion of HBsAg-/HBV DNA+(26/31720,0.08%)infections in the general population in Jiamusi.High sensitivity reagents should be used for HBV DNA testing to avoid missed testing.