甲状腺功能、肝功能指标相关性在甲状腺功能减退症诊治中的意义研究

The Significance of Correlation Between Thyroid Function and Liver Function in Diagnosis and Treatment of Hypothyroidism

目的探讨检验甲状腺功能和肝功能指标水平在甲状腺功能减退症(简称甲减)诊治中的临床意义,为临床实践提供了依据。方法回顾性研究2023年1—12月在福建省漳州市医院就诊的200例甲减患者(研究组)及同期参与健康体检的100例健康体检者(对照组)的临床检查资料。均先后接受甲状腺功能、肝功能指标检测,记录并分析相关指标水平差异,并对两者关系进行相关性分析。结果研究组的血清总三碘甲状腺原氨酸(total triiodothyronine,TT_(3))、总甲状腺素(total thyroxine,TT_(4))、游离三碘甲状腺原氨酸(free triiodothyronine,FT_(3))、游离甲状腺素(free thyroxine,FT_(4))水平均低于对照组,差异有统计学意义(P<0.05);促甲状腺激素(thyroid stimulating hormone,TSH)、总胆红素(total bilirubin,TBil)、丙氨酸转氨酶(alanine aminotransferase,ALT)、碱性磷酸酶(alkaline phosphatase,ALP)以及天冬氨酸转氨酶(aspartate aminotransferase,AST)水平均高于对照组,差异有统计学意义(P<0.05)。通过相关性分析显示,TSH水平与ALT、AST以及ALP呈正相关(r=0.465、0.625、0.567,P<0.05),TT_(3)、TT_(4)、FT_(4)与ALT呈负相关(r=-0.374、-0.344、-0.412,P<0.05),TT_(3)、TT_(4)、FT_(3)、FT_(4)与AST呈负相关(r=-0.341、-0.322、-0.373、-0.545,P<0.05),FT_(3)与ALP呈正相关(r=0.346,P<0.05)。结论甲减患者的甲状腺功能及肝功能指标均有一定程度变化,且两者存在相关性,实验室测定两项功能指标有助于早期防治甲减。

Objective To explore the clinical significance of testing thyroid function and liver function indicators in the diagnosis and treatment of hypothyroidism,and provide a basis for clinical practice.Methods A retrospective study was conducted on the clinical examination data of 200 hypothyroidism patients(study group)who visited in Zhangzhou Municipal Hospital of Fujian Province from January to December 2023,and 100 healthy individuals(control group)who participated in health examinations during the same period.They all underwent thyroid function and liver function index tests,recorded and analyzed the differences in related index levels,and conducted correlation analysis on the relationship between the two.Results The levels of serum total triiodothyronine(TT_(3)),total(TT_(3)),total thyroxine(TT_(4)),free triiodothyronine(FT_(3)),free thyroxine(FT_(4))were lower than those of the control group,with statistically significant difference(P<0.05).The levels of thyroid stimulating hormone(TSH),total bilirubin(TBil),alanine aminotransferase(ALT),alkaline phosphatase(ALP)and aspartate aminotransferase(AST)were higher than those of the control group,with statistically significant difference(P<0.05).Correlation analysis showed that TSH level was positively correlated with ALT,AST and ALP(r=0.465,0.625,0.567,P<0.05),while TT_(3),TT_(4),FT_(4) were negatively correlated with AST(r=-0.374,-0.344,-0.412,P<0.05),TT_(3),TT_(4),FT_(3),FT_(4) were negatively correlated with AST(r=-0.341,-0.322,-0.373,-0.545,P<0.05),and FT_(3) was positively correlated with ALP(r=0.346,P<0.05).Conclusion Thyroid function and liver function indicators in patients with hypothyroidism have changed to a certain extent,and there is a correlation between the two indicators.Laboratory measurement of these two indicators is helpful for early prevention and treatment of hypothyroidism.