盐酸氨溴索结合盐酸丙卡特罗治疗小儿肺炎的效果

Effect of Ambroxol Hydrochloride Combined with Procaterol Hydrochloride in the Treatment of Infantile Pneumonia

目的:分析小儿肺炎选择盐酸氨溴索、盐酸丙卡特罗联合治疗方案的价值。方法:选择泰安市妇幼保健院2019年10月—2020年8月收治的肺炎患儿160例,以随机数字表法分为两组。对照组(n=80)采取常规治疗,观察组(n=80)在常规治疗基础上配合盐酸氨溴索、盐酸丙卡特罗治疗。比较两组治疗效果、不良反应、临床症状体征消失时间及血清指标。结果:观察组总有效率较对照组高,差异有统计学意义(P<0.05);观察组症状体征消失时间均早于对照组,差异均有统计学意义(P<0.05);治疗后观察组C反应蛋白(C reactive protein,CRP)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、丙二醛(malondialdehyde,MDA)、一氧化氮(nitric oxide,NO)、动脉血二氧化碳分压(arterial partial pressure of carbon dioxide,PaCO_(2))水平均低于对照组,pH值、动脉血氧分压(arterial partial pressure of oxygen,PaO_(2))、超氧化物歧化酶(superoxide dismutase,SOD)水平均较对照组高,差异均有统计学意义(P<0.05)。结论:小儿肺炎选择盐酸氨溴索、盐酸丙卡特罗联合用药方案,可提升疗效,改善相关指标,促进患儿转归。

Objective:To analyze the value of Ambroxol Hydrochloride and Procaterol Hydrochloride combined therapy for infantile pneumonia.Method:A total of 160 children with pneumonia admitted to Tai’an Maternity and Child Health Hospital from October 2019 to August 2020 were selected and divided into two groups by random number table method.The control group(n=80)received conventional treatment,and the observation group(n=80)was treated with Ambroxol Hydrochloride combined with Procaterol Hydrochloride on the basis of conventional treatment.The therapeutic effect,adverse reactions,the disappearance time of clinical symptoms and signs and serum indexes were compared between the two groups.Result:The total effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).The disappearance time of symptoms and signs in observation group were earlier than those in control group,the differences were statistically significant(P<0.05).After treatment,the levels of C reactive protein(CRP),tumor necrosis factor-α(TNF-α),malondialdehyde(MDA),nitric oxide(NO)and arterial partial pressure of carbon dioxide(PaCO_(2))in the observation group were lower than those in the control group,and the pH value and the levels of arterial partial pressure of oxygen(PaO_(2))and superoxide dismutase(SOD)were higher than those in the control group,the differences were statistically significant(P<0.05).Conclusion:The combination medication regimen of Ambroxol Hydrochloride and Procaterol Hydrochloride in infantile pneumonia can improve the curative effect,improve the relevant indexes and promote the outcome of children.