基于数据挖掘技术探析李春红治疗紧张型头痛用药规律

Medication rule of Li Chunhong in treatment of tension-type headache:A study based on data mining

目的:通过数据挖掘方法探讨李春红教授治疗紧张型头痛的处方思路及用药规律,为临床治疗紧张型头痛提供参考。方法:收集整理2018年3月至2023年3月李教授诊治紧张型头痛的中药处方,运用Excel 2016、SPSS 19.0、SPSS Modeler 14.1软件进行药物组方规律分析。结果:共纳入处方343首,涉及中药114味,常用药物22味。用药以养血活血、理气化痰、疏风平肝类为主;关联规则分析得到53个常用药物组合;系统聚类分析得到核心药物组合4组,其中当归-川芎-柴胡-黄芩-清半夏-白芍为核心处方,其他药物组合依次为防风-羌活-白芷-天麻;茯苓-陈皮-炒枳实-党参-白术-泽泻;葛根-炒僵蚕-天花粉-生牡蛎-郁金-大黄。结论:李教授治疗紧张型头痛用药多从少阳入手,从血、气、风、痰论治,善用归芎剂、柴胡剂、疏风剂等经方合方加减,因人制宜。

Objective:To investigate the prescription and medication rules of Professor Li Chunhong in the treatment of tension-type headache based on data mining,and to provide a reference for the clinical treatment of tension-type headache.Methods:Traditional Chinese medicine(TCM)prescriptions were collected from the patients with tension-type headache who were treated by Professor Li from March 2018 to March 2023,and Excel 2016,SPSS 19.0,and SPSS Modeler 14.1 were used to analyze prescription rules.Results:A total of 343 prescriptions were included,involving 114 TCM drugs,among which there were 22 commonly used TCM drugs.Most drugs had the function of nourishing the blood and activating blood,regulating Qi and resolving phlegm,and dispelling wind and soothing the liver.The association rule analysis obtained 53 commonly used drug combinations,and the hierarchical cluster analysis obtained 4 core drug combinations,among which Angelica sinensis-Rhizoma Chuanxiong-Bupleurum chinense-Scutellaria baicalensis-Rhizoma Pinelliae Preparata-Radix Paeoniae Alba was the core prescription,while the other drug combinations were Saposhnicovia divaricata-notopterygium root-Radix Angelicae Dahuricae-Rhizoma Gastrodiae,Poria cocos-tangerine peel-roasted Fructus Aurantii Immaturus-Codonopsis pilosulaAtractylodes macrocephala Koidz.-Alisma orientalis,and Radix Puerariae-bran-fried Bombyx Batryticatus-Radix Trichosanthis-raw Concha Ostreae-Curcuma aromatica-Rheum officinale.Conclusion:In the treatment of tension-type headache,Professor Li often starts from Shaoyang for medication and performs treatment from blood,Qi,wind,and phlegm,using modified classical prescriptions and combined prescriptions such as Angelica sinensis-Rhizoma Chuanxiong prescriptions,Bupleurum chinense prescriptions,and wind-dispelling prescriptions based on the specific condition of each patient.